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| Name | Class |
|---|---|
| Fédération Française de Cardiologie | OTHER |
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The purpose of this study is to determine how monocyte HLA-DR and other markers of immune function change with time in neonates who underwent cardiac surgery with cardiopulmonary bypasss.
We hypothesize that HLA-DR expression in neonates is predictive of septic complications after cardiopulmonary bypass
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| neonates with cardiac surgery under cardiopulmonary bypass |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood collection | Other | A sample of an additional blood tube will be taken in parallel with the blood test carried out for the treatment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| HLA-DR expression | Number of HLA-DR molecules per monocyte (AB/c) determined by flow cytometry on whole blood using a Quantibrite phycoerythrin fluorescence quantitation kit (BD Biosciences) Number of HLA-DR molecules per monocyte (AB/c) determined by flow cytometry on whole blood using a Quantibrite phycoerythrin fluorescence quantitation kit (BD Biosciences) | Preoperatively, and 1, 2, 3 and 4 days after the end of cardiopulmonary bypass |
| Measure | Description | Time Frame |
|---|---|---|
| Cytokines measurements | Pro and anti-inflammatory cytokine concentrations in the plasma measured by multiplex immunoassay | Preoperatively, and 1, 2, 3 and 4 days after the end of cardiopulmonary bypass |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged ≤ 28 days after cardiac surgery under cardiopulmonary bypass
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| Name | Affiliation | Role |
|---|---|---|
| Alexis Chenouard, Dr | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | 44093 | France |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |