Mitochondrial Metabolism and Hepatic Complications of Obesity

Prospective Physiopathology Study of the Links Between Mitochondrial Dynamics and Fatty Liver Disease During Obesity

The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis.

The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis. The protocols involves a per-operative hepatic needle biopsy for mitochondria characterization and histological scoring of steatosis, inflammation, and fibrosis

Inclusion Criteria:

• adult men and women
• affiliated to a social security
• candidate for laparoscopic obesity surgery

Exclusion Criteria:

• Excessive alcohol consumption:> 20 g / day (woman),> 30 g / day (male)
• Chronic viral hepatitis B or C
• Genetic hemochromatosis
• Taking the following drugs for at least 3 months up to 6 months before the scheduled date of obesity surgery: systemic corticosteroids, amiodarone, methotrexate
• Wilson's disease
• autoimmune hepatitis
• alpha 1-antitrypsin deficiency
• abetalipoproteinemia
• Contraindications to liver biopsy