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The purpose of this study is to examine the effects of Mindfulness-Oriented Recovery Enhancement versus a social support group (supportive counseling) intervention for chronic pain patients receiving long-term opioid pharmacotherapy for pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mindfulness-Oriented Recovery Enhancement | Experimental |
| |
| Supportive Counseling | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mindfulness-Oriented Recovery Enhancement | Behavioral | Mindfulness-Oriented Recovery Enhancement (MORE) is a group behavioral intervention led by a therapist that combines training in mindfulness, cognitive reappraisal, and savoring skills. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in pain symptoms | Pain severity and interference as measured by the Brief Pain Inventory | Change from baseline through study completion (9 months post-treatment) |
| Change in aberrant drug-related behaviors | Aberrant drug-related behaviors as evidenced by triangulated aggregate of Current Opioid Misuse Measure and/or clinician assessment via Addiction Behaviors Checklist and/or urine screen | Change from baseline through study completion (9 months post-treatment) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in emotional distress | Distress measured by the Depression, Anxiety, Stress Scale | Change from baseline through study completion (9 months post-treatment) |
| Change in opioid dose | Opioid dose converted into morphine equivalents via standardized equianalgesic tables |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cue-reactivity | Change in EEG responses during a cue-reactivity task | Change from baseline through 8 weeks |
| Change in emotion regulation | Change in EEG responses during an emotion regulation task |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| College of Social Work | Salt Lake City | Utah | 84112 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32915027 | Derived | Garland EL, Hudak J, Hanley AW, Nakamura Y. Mindfulness-oriented recovery enhancement reduces opioid dose in primary care by strengthening autonomic regulation during meditation. Am Psychol. 2020 Sep;75(6):840-852. doi: 10.1037/amp0000638. | |
| 31556669 | Derived | Garland EL, Hanley AW, Riquino MR, Reese SE, Baker AK, Salas K, Yack BP, Bedford CE, Bryan MA, Atchley R, Nakamura Y, Froeliger B, Howard MO. Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial. J Consult Clin Psychol. 2019 Oct;87(10):927-940. doi: 10.1037/ccp0000390. |
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| ID | Term |
|---|---|
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D012657 | Self-Help Groups |
| ID | Term |
|---|---|
| D009938 | Organizations |
| D004472 | Health Care Economics and Organizations |
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| Supportive Counseling | Behavioral | A support group led by a therapist will allow participants to express emotions, share experiences, and receive social support. |
|
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| Change from baseline through study completion (9 months post-treatment) |
| Change in opioid craving | Craving measured by visual analogue scale | Change from baseline through study completion (9 months post-treatment) |
| Change in interoceptive awareness | Interoceptive awareness measured by the Multidimensional Assessment of Interoceptive Awareness | Change from baseline through 8 weeks |
| Change in reappraisal | Reappraisal measured by the Emotion Regulation Questionnaire | Change from baseline through 8 weeks |
| Change in savoring | Savoring measured by the brief Ways of Savoring checklist | Change from baseline through 8 weeks |
| Change in meditative experiences | As measured by the Five Facet Mindfulness Questionnaire, self-salience and self-extension items, and/or Nondual Awareness Dimensional Assessment | Change from baseline through 8 weeks |
| Change in body sensations | Change in pleasant, neutral, and unpleasant body sensations as measured by body map | Change from baseline through 8 weeks |
| Change from baseline through 8 weeks |