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The aim of the work is to determine whether the use of immunomodulatory drugs could improve the reproductive of outcome of infertile patients who have autoimmune thyroiditis with positive autoimmune antibodies undergoing IVF-ET.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Experimental | Patients will receive thyroxine , low dose aspirin , low dose selenium, Calcium and vitamin D and immunomodulatory drugs(prednisolone, hydroxychloroquine, azathioprin, IV immunoglobulins) |
|
| Control group | Active Comparator | Patients will receive thyroxine , low dose aspirin , low dose selenium, Calcium and vitamin D. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immunomodulatory | Drug | Patients will receive thyroxine , low dose aspirin , low dose selenium, Calcium and vitamin D before ICSI cycle. Moreover, patients will receive a treatment course of immunomodulatory drugs for 3 -6 months before ICSI cycle:
|
| Measure | Description | Time Frame |
|---|---|---|
| The Number of Participants Who Achieved clinical Pregnancy | 6 weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| The Number of Participants Who Achieved Ongoing Pregnancy | 18 weeks after embryo transfer |
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Inclusion Criteria:
Exclusion Criteria:
Patients who have any medical disorders ( eg. D.M. HTN .Epilepsy ….)
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| Name | Affiliation | Role |
|---|---|---|
| Ahmed M Sayed, Prof. | Aljazeera (Al Gazeera) hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aljazeera (Al Gazeera) hospital | Giza | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D013967 | Thyroiditis, Autoimmune |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D013966 | Thyroiditis |
| D013959 | Thyroid Diseases |
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| ID | Term |
|---|---|
| D013974 | Thyroxine |
| ID | Term |
|---|---|
| D013963 | Thyroid Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D024322 | Amino Acids, Aromatic |
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|
| Thyroxine | Drug | Patients will receive thyroxine , low dose aspirin , low dose selenium, Calcium and vitamin D before ICSI cycle. Patients will not receive immunomodulatory drugs |
|
| D004700 |
| Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |