Cryoablation combined with chemotherapy on the quality of life of patients with non resectable esophageal or gastroesophageal cancer.

This is a single arm prospective study to determine the effect of cryoablation combined with chemotherapy on the quality of life of patients with non resectable esophageal or gastroesophageal cancer.

Inclusion Criteria:

• Has esophageal or gastroesophageal cancer and will be receiving chemotherapy
• Dysphagia score of 1, 2, 3 or 4.
• Age ≥18 years old
• American Society of Anesthesiologists (ASA) Physical Status Classification ≤ 4
• Deemed not a candidate for esophageal cancer surgical resection
• Female subjects must be either post-menopausal, surgically sterilized, or willing to use an acceptable method of birth control (i.e., total abstinence, birth control pills, an intrauterine device (IUD), diaphragm, progesterone injections or implants, or condoms plus a spermicide) for the duration of the study

Exclusion Criteria:

• Eastern Cooperative Oncology Group (ECOG) performance status greater than 2
• Patient who received radiation treatment in the prior 8 weeks
• Known brain metastases causing cranial nerve deficits which can cause dysphagia
• Inability to undergo an esophagogastroduodenoscopy (EGD)
• Pregnant or nursing
• Surgery or anatomy where capacity of stomach is reduced making cryotherapy contraindicated
• Patients with tracheoesophageal fistula

patients with non resectable esophageal cancer