Quality of Life Assessment of Cryotherapy in Esophageal or Gastroesophageal Cancer

Quality of Life Assessment in Patients Receiving Cryotherapy in Addition to Chemotherapy for Palliation of Unresectable Esophageal or Gastroesophageal Cancer

Cryoablation combined with chemotherapy on the quality of life of patients with non resectable esophageal or gastroesophageal cancer.

This is a single arm prospective study to determine the effect of cryoablation combined with chemotherapy on the quality of life of patients with non resectable esophageal or gastroesophageal cancer.

Inclusion Criteria:

• Has esophageal or gastroesophageal cancer and will be receiving chemotherapy
• Dysphagia score of 1, 2, 3 or 4.
• Age ≥18 years old
• American Society of Anesthesiologists (ASA) Physical Status Classification ≤ 4
• Deemed not a candidate for esophageal cancer surgical resection
• Female subjects must be either post-menopausal, surgically sterilized, or willing to use an acceptable method of birth control (i.e., total abstinence, birth control pills, an intrauterine device (IUD), diaphragm, progesterone injections or implants, or condoms plus a spermicide) for the duration of the study

Exclusion Criteria:

• Eastern Cooperative Oncology Group (ECOG) performance status greater than 2
• Patient who received radiation treatment in the prior 8 weeks
• Known brain metastases causing cranial nerve deficits which can cause dysphagia
• Inability to undergo an esophagogastroduodenoscopy (EGD)
• Pregnant or nursing
• Surgery or anatomy where capacity of stomach is reduced making cryotherapy contraindicated
• Patients with tracheoesophageal fistula