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The purpose is to show that bifocal tDCS with an anodal stimulation on the orbitofrontal cortex and cathodic stimulation on supplementary motor areas is an effective treatment for patients with resistant and severe obsessive compulsive disorders.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bifocal stimulation | Experimental | Transcranial direct current Bifocal stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bifocal stimulation with tDCS | Other | Patients will receive an active Treatment with tDCS (10 sessions of 30 mn with an intensity of 2 mA) |
|
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome measure is used to show that bifocal tDCS with anodal stimulation on OFC and cathodic stimulation on the SMA is an effective treatment | Score improvement on the Y-BOCS after 14 days compared to the baseline | Day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the persistence of therapeutic response at 45 days | Score improvement on the Y-BOCS after 45 days compared to the baseline | Day 45 |
| Evaluate the persistence of therapeutic response at 105 days |
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Patients must present all of the following criteria in order to be eligible:
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nematollah JAAFARI, Professor | Centre Hospitalier Henri Laborit | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Henri Laborit | Poitiers | 86021 | France |
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| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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Score improvement on the Y-BOCS after 105 days compared to the baseline
| Day 105 |
| Evaluate the therapeutic effect of tDCS on the depressive and anxious symptoms associated with Obsessive compulsive disorder at 14 days | Score improvement of Hamilton and HDRS scales between the baseline and day 14 | Day 14 |
| Evaluate the therapeutic effect of tDCS on the depressive and anxious symptoms associated with Obsessive compulsive disorder at 45 days | Score improvement of Hamilton and HDRS scales between the baseline and day 45 | Day 45 |
| Evaluate the therapeutic effect of tDCS on the depressive and anxious symptoms associated with Obsessive compulsive disorder at 105 days | Score improvement of Hamilton and HDRS scales between the baseline and day 105 | Day 105 |
| Evaluate the effect of tDCS on the quality of life at day 14 | Improvement of MOS SF-36 scale (Medical Outcome Study, Short Form) between baseline and day 14 | Day 14 |
| Evaluate the effect of tDCS on the quality of life at day 45 | Improvement of MOS SF-36 scale (Medical Outcome Study, Short Form) between baseline and day 45 | Day 45 |
| Evaluate the effect of tDCS on global functioning at day 14 | Improvement of GAF (Global Assessment of Functioning) scale between baseline and day 14 | Day 14 |
| Evaluate the effect of tDCS on global functioning at day 45 | Improvement of GAF (Global Assessment of Functioning) scale between baseline and day 45 | Day 45 |
| Evaluate the effect of tDCS on social adjustment at day 14 | Improvement of SAS (Social Adjustment Scale) scale between baseline and day 14 | Day 14 |
| Evaluate the effect of tDCS on social adjustement at day 45 | Improvement of SAS (Social Adjustment Scale) scale between baseline and day 45 | Day 45 |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |