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This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arms A | Experimental | Strategy 1 - Washout period - Strategy 2 |
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| Arms B | Experimental | Strategy 2 - Washout period - Strategy 1 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strategy 1 | Other | PEEP titration according to transpulmonary-end-expiratory pressure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Short-term effects of 2 PEEP titration strategies on gas exchange | 2 hours 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Short-term effects of 2 PEEP titration strategies on respiratory mechanics | 2 hours 15 min | |
| Short-term effects of 2 PEEP titration strategies on hemodynamics | 2 hours 15 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Study Official is required by the WHO and BELONCLE, Ass.Pr | Contact | 0241353845 | Francois.Beloncle@chu-angers.fr |
| Name | Affiliation | Role |
|---|---|---|
| Study Official is required by the WHO and BELONCLE, Ass.Pr | Angers teatching hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Recruiting | Angers | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41024114 | Derived | Chean D, Courtais A, Pavlovsky B, Yvin E, Desprez C, Taillantou-Candau M, Piquilloud L, Richard JC, Mercat A, Beloncle FM. Comparison of two transpulmonary pressure-based positive end-expiratory pressure titration strategies in acute respiratory distress syndrome: a randomized crossover study. Crit Care. 2025 Sep 29;29(1):409. doi: 10.1186/s13054-025-05626-x. |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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| Strategy 2 | Other | PEEP titration according to chest wall elastance measurement |
|