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It remains unknown if the association between moderate to low intensity statin therapy and ezetimibe and nutraceuticals might have a therapeutic role in high-intensity statin intolerant patients
The aim of this study will be to evaluate whether the association between statin and exetimibe vs statin + ezetimibe + nutraceuticals can lead to higher percentage of LDL target achievement
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| statin + ezetimibe | Active Comparator | Low dose statin associated with ezetimibe |
|
| statin + ezetimibe + Nutraceuticals | Active Comparator | Low dose statin associated with ezetimibe and Nutraceuticals |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| statin + ezetimibe | Drug | Combination of two drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| Therapeutic target | LDL cholesterol < 70 mg/dl | Up to 3 months |
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Inclusion Criteria:
Patients with angiographically assessed diagnosis of coronary artery disease
Exclusion Criteria:
None
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francesco Pelliccia, MD | Contact | 39064997 | 123 | f.pelliccia@mclink.it |
| Giuseppe Marazzi, MD | Contact | 39064997 | 456 | marazzig@gmai.com |
| Name | Affiliation | Role |
|---|---|---|
| Carlo Gaudio, MD | Sapienza University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sapienza University | Rome | 00161 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30420184 | Derived | Marazzi G, Campolongo G, Pelliccia F, Calabro Md P, Cacciotti L, Vitale C, Massaro R, Volterrani M, Rosano G. Usefulness of Low-Dose Statin Plus Ezetimibe and/or Nutraceuticals in Patients With Coronary Artery Disease Intolerant to High-Dose Statin Treatment. Am J Cardiol. 2019 Jan 15;123(2):233-238. doi: 10.1016/j.amjcard.2018.09.041. Epub 2018 Oct 19. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| D000069438 | Ezetimibe |
| D019587 | Dietary Supplements |
| ID | Term |
|---|---|
| D000924 | Anticholesteremic Agents |
| D000960 | Hypolipidemic Agents |
| D000963 | Antimetabolites |
| D045504 | Molecular Mechanisms of Pharmacological Action |
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| statin + ezetimibe + Nutraceuticals | Drug | Combination of two grus plus nutraceuticals |
|
|
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D004791 | Enzyme Inhibitors |
| D057847 | Lipid Regulating Agents |
| D045506 | Therapeutic Uses |
| D001384 | Azetidines |
| D001385 | Azetines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |