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| Name | Class |
|---|---|
| Dementias Platform UK | UNKNOWN |
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The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment.
The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline.
Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests.
The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitively normal controls (CNC) | No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described |
| |
| Subjective cognitive decline (SCD) | Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described |
| |
| Mild cognitive impairment (MCI) | Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described |
| |
| Alzheimer's dementia | Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP |
| |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurocognitive battery | Diagnostic Test | Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted). NACC: Story recall, Benson's complex figure copy, colour trail test (black & white), verbal fluency, digit forward and backward span. |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive decline | Change in total HK-MoCA score between baseline and follow-up | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Functional decline | Change in Lawton's IADL score between baseline and follow-up | 1 year |
| Neuropsychiatric decline | Change in Neuropsychiatric Index (NPI) between baseline and follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joseph SK Kwan, MD | Contact | +85222554769 | jskkwan@hku.hk | |
| Charlene Cheng, BA | Contact | +85222554769 | cychar@hku.hk |
| Name | Affiliation | Role |
|---|---|---|
| Joseph SK Kwan, MD | The University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medicine, Queen Mary Hospital, The University of Hong Kong | Recruiting | Hong Kong | Hong Kong |
Share with Dementias Platform UK (www.dementiasplatform.uk)
Due to be shared from 2017, indefinitely.
Via Dementias Platform UK (www.dementiasplatform.uk)
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| ID | Term |
|---|---|
| D019965 | Neurocognitive Disorders |
| D060825 | Cognitive Dysfunction |
| D000544 | Alzheimer Disease |
| D015140 | Dementia, Vascular |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| D004569 | Electroencephalography |
| D005071 | Evoked Potentials |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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Venous blood at baseline and at yearly follow up
| Vascular dementia |
Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP |
|
|
| MRI | Diagnostic Test | MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients |
|
| Blood tests | Biological | Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis |
|
| EEG with event-related potential (ERP) | Diagnostic Test | 128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients |
|
| Amyloid PET CT | Diagnostic Test | F18 Flutametamol PET CT for selected patients |
|
| 1 year |
| Quality of life decline | Change in QoL-AD score between baseline and follow-up | 1 year |
| Change in cognitive impairment status | Progression to mild cognitive impairment (MCI) or dementia status | 1 year |
| D009422 |
| Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D002561 | Cerebrovascular Disorders |
| D002537 | Intracranial Arteriosclerosis |
| D020765 | Intracranial Arterial Diseases |
| D056784 | Leukoencephalopathies |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D003943 | Diagnostic Techniques, Neurological |
| D004568 | Electrodiagnosis |
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
| D010829 | Physiological Phenomena |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |