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Systemic inflammation caused by surgery may aggravate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. ketamine, a N-methyl-D-asparate receptor antangonist, has anti-inflammatory activity and opioid-sparing effect. This study investigate the effect of intraopertaive ketamine administration on immune function in patients undergoing laparoscopic colorectal cancer resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ketamine group | Experimental | Ketamine is administered intravenously with a loading dose of 0.25 mg/kg at 5 minutes before surgery, followed by an infusion rate of 0.05 mg/kg/h to the end of surgery. |
|
| control group | Placebo Comparator | 0.9% saline solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketamine | Drug | Ketamine is administered intravenously with a loading dose of 0.25 mg/kg at 5 minutes before surgery, followed by an infusion rate of 0.05 mg/kg/h to the end of surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | Baseline |
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | 1 hour after surgery |
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | postoperative day 1 |
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | postoperative day 2 |
| Measure | Description | Time Frame |
|---|---|---|
| proinflammatory cytokine | Inflammtory response is assesssed by measuring levels of proinflammtory cytokines. | Baseline |
| proinflammatory cytokine | Inflammtory response is assesssed by measuring levels of proinflammtory cytokines. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jin Sun Cho, MD | Contact | 82-2-2228-5448 | chjs0214@yuhs.ac |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine | Recruiting | Seoul | 03722 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33532995 | Derived | Cho JS, Kim NY, Shim JK, Jun JH, Lee S, Kwak YL. The immunomodulatory effect of ketamine in colorectal cancer surgery: a randomized-controlled trial. Can J Anaesth. 2021 May;68(5):683-692. doi: 10.1007/s12630-021-01925-3. Epub 2021 Feb 2. |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D007649 | Ketamine |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
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| Saline | Drug | 0.9% saline solution |
|
| 1 hour after surgery |
| proinflammatory cytokine | Inflammtory response is assesssed by measuring levels of proinflammtory cytokines. | postoperative day 1 |
| proinflammatory cytokine | Inflammtory response is assesssed by measuring levels of proinflammtory cytokines. | postoperative day 2 |
| recurrence | Cancer recurrence is evaluated 1 year after surgery. | 1 year after surgery |
| metastasis | Cancer metastasis is evaluated 1 year after surgery. | 1 year after surgery |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |