The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection

The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection

Systemic inflammation caused by surgery may aggravate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. ketamine, a N-methyl-D-asparate receptor antangonist, has anti-inflammatory activity and opioid-sparing effect. This study investigate the effect of intraopertaive ketamine administration on immune function in patients undergoing laparoscopic colorectal cancer resection.

Inclusion Criteria:

• patient between 20 and 80 of age with ASA physical status Ⅰ-Ⅲ
• patient scheduled for laparoscopic colorectal cancer resection

Exclusion Criteria:

• ASA physical status Ⅳ
• severe hepatorenal disease
• heart failure
• infection
• increased intracranial pressure, seizure
• preoperative chemotherapy
• immune or endocrine disease
• metastasis to other organ
• problem with communication
• pregnancy
• body mass index > 35 kg/m2