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The main objective of this study is to compare the effect of the non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
There is evidence supporting that OSAS is an independent risk factor for cardiovascular and cerebrovascular diseases such as hypertension, congestive heart failure, myocardial infarction, cardiac-arrhythmia, and stroke.Gender, age, smoking, obesity and diabetes, which are risk factors for periodontitis,It is also common in OSAS at the same time.In addition to common risk factors, both OSAS and periodontitis have been shown to be associated with increased oxidative stress markers.
The investigators aimed to investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: Non-surgical periodontal therapy in patient with OSAS and Periodontitis | Experimental | Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Individuals: with both OSAS and periodontitis Intervention: Procedure: Non-surgical periodontal therapy |
|
| Control: non-surgical periodontal therapy in Periodontitis | Active Comparator | Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Individuals: only periodontitis Intervention: Procedure: Non-surgical periodontal therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Experimental | Other | Experimental: Non-surgical periodontal therapy in patient with OSAS and Periodontitis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum Total Antioxidant Status (TAS) level (millimolar per liter (mmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Serum Total Oxidant Status (TOS) level (mikromolar per liter (µmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Serum Oxidative Stress Index (OSI) level : TOS/TAS | Changes in serum and salivary oxidative stress parameters | 3 months |
| Serum Native Thiol (mikromolar per liter (µmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Serum Thiol/disulfid (millimolar per liter (mmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Saliva Total Antioxidant Status (TAS) level (millimolar per liter (mmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Saliva Total Oxidant Status (TOS) level (mikromolar per liter (µmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Saliva Oxidative Stress Index (OSI) level : TOS/TAS |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index (PI) | Change in clinical measures of chronic periodontitis | 3 months |
| Gingival Index (GI) | Change in clinical measures of chronic periodontitis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zeliha Betul Özsağır | Bezmialem VU | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bezmialem Vakıf University, Faculty of Dentistry, Deparment of Periodontology, | Istanbul | 34093 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25299385 | Background | Loke W, Girvan T, Ingmundson P, Verrett R, Schoolfield J, Mealey BL. Investigating the association between obstructive sleep apnea and periodontitis. J Periodontol. 2015 Feb;86(2):232-43. doi: 10.1902/jop.2014.140229. Epub 2014 Oct 9. | |
| 27858556 | Result | Gamsiz-Isik H, Kiyan E, Bingol Z, Baser U, Ademoglu E, Yalcin F. Does Obstructive Sleep Apnea Increase the Risk for Periodontal Disease? A Case-Control Study. J Periodontol. 2017 May;88(5):443-449. doi: 10.1902/jop.2016.160365. Epub 2016 Nov 18. |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D012891 | Sleep Apnea Syndromes |
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It's an assessor blinded, parallel group, randomized controlled trial aimed at investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
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| Control | Other | Control: Non-surgical periodontal therapy in Periodontitis |
|
Changes in serum and salivary oxidative stress parameters |
| 3 months |
| Saliva Native Thiol (mikromolar per liter (µmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| Saliva Thiol/disulfid (millimolar per liter (mmol /L)) | Changes in serum and salivary oxidative stress parameters | 3 months |
| 3 months |
| Bleeding on probing (BOP) | Change in clinical measures of chronic periodontitis | 3 months |
| Clinical attachment loss(CAL) | Change in clinical measures of chronic periodontitis | 3 months |
| Probing pocket depth (PD) | Change in clinical measures of chronic periodontitis | 3 months |
| 24080100 | Result | DPTT study group; Engebretson S, Gelato M, Hyman L, Michalowicz BS, Schoenfeld E. Design features of the Diabetes and Periodontal Therapy Trial (DPTT): a multicenter randomized single-masked clinical trial testing the effect of nonsurgical periodontal therapy on glycosylated hemoglobin (HbA1c) levels in subjects with type 2 diabetes and chronic periodontitis. Contemp Clin Trials. 2013 Nov;36(2):515-26. doi: 10.1016/j.cct.2013.09.010. Epub 2013 Sep 27. |
| D001049 |
| Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |