Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in OSAS

Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in Obstructive Sleep Apnea Syndrome (OSAS)

The main objective of this study is to compare the effect of the non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.

There is evidence supporting that OSAS is an independent risk factor for cardiovascular and cerebrovascular diseases such as hypertension, congestive heart failure, myocardial infarction, cardiac-arrhythmia, and stroke.Gender, age, smoking, obesity and diabetes, which are risk factors for periodontitis,It is also common in OSAS at the same time.In addition to common risk factors, both OSAS and periodontitis have been shown to be associated with increased oxidative stress markers.

The investigators aimed to investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.

Inclusion Criteria:

• aged ≥18 years old
• having more than 16 teeth
• BMI>25 kg/m2

Exclusion Criteria:

• patients with a history of diabetes mellitus or respiratory diseases
• patients who were under any medication that was known to influence periodontal tissues
• patients with a history of any periodontal treatment in the past 6 months
• patients with hormonal changes such as pregnancy or lactation; and 5) patients having fixed dentures or removable prothesis
• OSAS treatment started (using OSAS therapy device or undergoing surgical operation)