Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study

Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study

To investigate the effect of metformin on pregnancy complications and pregnancy outcome in the II. and III. trimester of pregnancy in women with polycystic ovary syndrome.

Inclusion Criteria:

• diagnosis polycystic ovary syndrome (PCOS ) before pregnancy
• BMI 27-40 kg/m2
• Human chorionic gonadotropin, beta subunit (HCG-beta) verified pregnancy week 5-8
• At least one of the following criteria: (1) serum testosteron > 2,5 nmol/L; (2) Sex hormone binding globulin (SHBG) < 30 nmol; (3) Fasting C-peptid > 1,0 nmol/L; (4) Menstrual disturbances: oligo-/amenorrhea or metrorrhagia; (5) Hirsutism

Exclusion Criteria:

• known liver disease or ALAT > 60 IU/L
• S-creatinin > 130 micromol/L
• diabetes mellitus
• alcohol or drug abuse
• peroral steroid treatment (except inhalation steroids)
• use of cimetidine, anticoagulant, erythromycin or other macrolides
• not suitable for other reasons