Metformin in Pregnant PCOS Women

Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome (PCOS)

To investigate the effect of metformin on pregnancy complications and pregnancy outcome in the II. and III. trimester of pregnancy in women with polycystic ovary syndrome.

Inclusion Criteria:

• 18-45 years,
• PCOS diagnosis according to Rotterdam criteria
• single, viable, ultrasound verified fetus
• if metformin was used at conception and early pregnancy, at least 7 days of "wash out"

Exclusion Criteria:

• known liver disease or ALAT > 90 nmol/L
• known renal disease or creatinine > 110 micromol/L
• diabetes mellitus
• alcohol or drug abuse
• peroral steroid treatment
• cimetidine, anticoagulant or erythromycin treatment at time of inclusion
• not suitable for other reasons