Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

In order to improve treatment outcome for cannabis use disorder (CUD), the investigators have developed a laboratory model to investigate the effects of potential treatment medications on cannabis withdrawal and on the subjective and reinforcing effects of cannabis in non treatment-seeking cannabis smokers. In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Inclusion Criteria:

• Current cannabis use
• Able to give informed consent and perform study procedures
• Women practicing an effective form of birth control
• English speaking

Exclusion Criteria:

• Presence of any clinically significant medical diagnoses
• History of heart disease and cardiac risk factors, severe chronic obstructive pulmonary disease, uncontrolled hypertension, or diabetes
• Current parole or probation
• Certain psychiatric diagnoses
• Current pregnancy or lactation