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The purpose of this study is to test the efficacy of delivering an exercise and healthy lifestyle program, Smart Aging, to older adults.
The Smart Aging Program is designed to be scalable, implementable, and sustainable in the real world. This program joins patients and their clinicians with community-based fitness centers. The Smart Aging Program looks to use already existing resources to deliver an innovative program to increase physical activity in older adults.
The program begins at the patient-physician level. The program is conducted in community-based fitness centers, the participant's home (home exercise, monitoring) and also sends physical activity data back to the clinician using mobile technology.
The Smart Aging Program consists of a personalized and structured exercise program combined with lifestyle education and mobile-health monitoring. The exercise program includes a 12-week initiation phase, followed by a 40-week maintenance phase.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Smart Aging Program | Experimental | Participants will be enrolled into the Smart Aging Program. |
|
| Control Group | Active Comparator | Participants will be enrolled into group that receives educational materials that reflect the current standard of care. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Smart Aging Program | Behavioral | Comprehensive lifestyle and fitness program designed to improve the health of older adults. The Smart Aging Program represents a package consisting of a dedicated health coach, mobile monitoring, specialized curriculum, and exercise opportunities. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Cardiorespiratory Fitness | Measured by peak oxygen consumption (VO2 peak) during treadmill testing. | Change from Baseline to 12 Weeks |
| Change in Cardiorespiratory Fitness | Measured by peak oxygen consumption (VO2 peak) during treadmill testing. | Change from Baseline to 52 Weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Insulin Resistance | Measured using Homeostasis Model Assessment 2. | 52 Weeks |
| Change in Fat Mass | Measured using a dual energy x-ray absorptiometry (DEXA) scan. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeffrey Burns, MD | University of Kansas Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41298205 | Derived | Holden R, Szabo-Reed AN, Watts A, Clutton J, Finley K, Wolff SF, Burns JM. Physician referral is associated with recruitment, motivation, and adherence in an exercise intervention study for older adults. J Natl Med Assoc. 2026 Feb;118(1):103-112. doi: 10.1016/j.jnma.2025.11.002. Epub 2025 Nov 15. | |
| 39376152 | Derived |
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| ID | Term |
|---|---|
| D015438 | Health Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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|
| Educational Materials | Behavioral | Current standard of care. Includes education materials covering benefits of a healthy lifestyle. |
|
| 52 Weeks |
| Change in Lean Mass | Measured using a dual energy x-ray absorptiometry (DEXA) scan. | 52 Weeks |
| Change in Cholesterol | Changes in total cholesterol, LDL, and HDL will be measured. | 52 Weeks |
| Watts A, Szabo-Reed A, Baker J, Morris JK, Vacek J, Clutton J, Mahnken J, Key MN, Vidoni ED, Burns JM. LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine. Alzheimers Dement. 2024 Dec;20(12):8374-8386. doi: 10.1002/alz.14265. Epub 2024 Oct 8. |