The Aortic Valve DECalcification (AVADEC) Trial

The Effects of Menaquinone-7 Supplementation in Patients With Aortic Valves Calcification

Aortic stenosis is a common heart valve disease and due to the growing elderly population the prevalence is increasing. The disease is progressive with increasing calcification of the valve cusps. A few attempts with medical preventive treatment have failed, thus presently the only effective treatment of aortic stenosis is surgery. This study will examine the effect of menaquinone-7 (MK-7) supplementation on progression of aortic valve calcification (AVC). The investigators hypothesize that MK-7 supplementation will slow down the calcification process.

Inclusion Criteria:

Participants in the Danish Cardiovascular Screening Trial (Trials. 2015 Dec 5;16:554) with an aortic valve calcification score above 300, but without aortic valve stenosis are eligible.

Exclusion Criteria:

• Known aortic valve disease (peak velocity ≥3.0 m/s)
• History of venous thrombosis or other coagulation disorders or use of vitamin K antagonists
• Disorders of calcium and phosphate metabolism
• A life-expectancy < 5 years