Vitamin K Supplement for Inhibition of the Progress in Aortic Valve Calcification

Vitamin K Containing Nutritional Supplement for Activation of Matrix-GIa-proteins (MGP) and Inhibition of Aortic Valve Calcification Process

In this mono-center,open,three-armes, controlled, randomized phase I study the progress of aortic valve calcification with and without vitamin K supplementation will be investgated. This will be done by means of measurements of concentrations from osteocalcine and MPG in blood serum, echocardiography, cardiac computed tomography and cardiac MRI

Patients will be allocated to two groups with either

1. additional intake of 2 mg vitamin k1 daily
2. controll group without additional intake of Vitamin K

Treatment group a will include 100 patients, the controll group should include 100 patients. None of all patients should require renal dialysis.

Inclusion Criteria:

• aortic valve calcification,verified by echocardiography

Exclusion Criteria:

• chronic or acute intestinal diseases
• terminal renal failure
• allergic reaction on soya containing products
• recent additional intake of vitamin K
• oral anticoagulation with vitamin K antagonists (Marcoumar)
• systemic therapy with corticosteroids
• anamnestic venous thrombosis (pelvet or legs)or embolization of lung arteria
• pregnant or breastfeeding women
• persons without mental ability or capacity to understand and follow the instructions of the investigator
• women of childbearing age without safe contraceptional devices
• minority