Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen(DPANDA) Study

Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen

The registry study aims to determine serial biomarkers to diagnosis and prognosis of aortic aneurysm/aortic dissection.

The study aims to investigate the role of candidate biomarkers in the diagnosis and prognosis of AA and AD. In the diagnosis part, we begin with a discovery phase where individually matched case-control study. Patients within each disease outcomes (i.e. AD, AMI, PE, AA without AD and healthy controls) are age and sex matched and retrospectively included.In the prognosis part of the study, patients with confirmed AA and AD are enrolled. The primary outcome is the all-cause mortality based on the death certificates. The secondary outcome is the in-hospital mortality according to the patients'medical records.

Inclusion Criteria:

Retrospective

• All patients who were referred to the surgical service for evaluation and management of aortic dissection were included.

Perspective

• Patients with initial suspicion of having AAD were perspectively enrolled.

Exclusion Criteria:

Retrospective

• Patients who received packed red blood cells, whole blood, or platelets less than 10 days before the blood sample was taken;
• Patients with aortic trauma, pseudo aneurysm, history of heart failure, renal dysfunction, severe pulmonary diseases, or active cancer;
• Patients who entered the hospital for checkups after surgery.

Perspective

• Patients in whom there is little or no suspicion of a life-threatening disease;
• Patients with confirmed acute myocardial infarction,angina or pulmonary embolism
• The symptoms were clearly not related to AD (e.g. pleurisy, pneumonia, acute abdominal diseases).