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This study aims to evaluate the long term effect of deep brain stimulation in the the subthalamic nucleus (STN) in patients with Parkinson's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| STN DBS | Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS) of the subthalamic nucleus (STN) | ||
| CONTROL | Parkinson's disease (PD) patients received optimized medical treatment according to published evidence based guidelines |
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| Measure | Description | Time Frame |
|---|---|---|
| Changs in the score of Stand-Walk-Sit Test | above 10 years post surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the score in United Parkinson Disease Rating Scale (UPDRS) part III | above 10 years post surgery | |
| UPDRS part I score | above 10 years post surgery | |
| UPDRS part II score |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with Parkinson's Disease who underwent STN DBS for above 10 years or Patients with Parkinson's Disease whose disease duration longer than 15 years.
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| Name | Affiliation | Role |
|---|---|---|
| Haiyan Zhou | Ruijin Hospital | Principal Investigator |
| Dianyou Li | Ruijin Hospital | Principal Investigator |
| Bomin Sun | Ruijin Hospital | Principal Investigator |
| Wei Hu | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine | Shanghai | China |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| above 10 years post surgery |
| UPDRS part IV score | above 10 years post surgery |
| 39-Item Parkinson´s Disease Questionnaire (PDQ-39) score | above 10 years post surgery |
| Freezing of Gait Questionnaire (FOG-Q) score | above 10 years post surgery |
| Gait and Falls Questionnaire (GFQ) score | above 10 years post surgery |
| Mini-Mental State Examination (MMSE) score | above 10 years post surgery |
| Montreal Cognitive Assessment (MoCA) Beijing score Version | above 10 years post surgery |
| Frontal Assessment Battery (FAB) score | above 10 years post surgery |
| Hamilton Anxiety Scale (HAMA) score | above 10 years post surgery |
| Hamilton Depression Scale-17 (HAMD-17) score | above 10 years post surgery |
| Apathy Evaluation Scale score | above 10 years post surgery |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |