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| ID | Type | Description | Link |
|---|---|---|---|
| Grant 01 GI 0201/01 GI 0401 |
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Assessment of the therapeutic effect of deep brain stimulation of the subthalamic nucleus compared with drug treatment alone in patients with advanced Parkinson's disease.
Patients are randomized either to medical treatment or subthalamic stimulation. The observation period was 6 months. The primary outcome criterium: PDQ-39 and UPDRS III.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Implantation of stimulation electrodes in the STN | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life | ||
| Motor Score in the OFF (UPDRS III) |
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Inclusion Criteria:
advanced Parkinson's disease with UPDRS III score >29/104 or Dyskinesia score > 2 or tremor >2
Exclusion Criteria:
age>75 years depression psychosis surgical contraindications
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| Name | Affiliation | Role |
|---|---|---|
| Guenther Deuschl, Prof. | Department of Neurology, Christian-Albrechts University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neurologische Klinik der Charité, Augustenburgerplatz 1 | Berlin | 13353 | Germany | |||
| Neurologische Klinik der Universität, Gleuelerstr. 50 |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16943402 | Result | Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schafer H, Botzel K, Daniels C, Deutschlander A, Dillmann U, Eisner W, Gruber D, Hamel W, Herzog J, Hilker R, Klebe S, Kloss M, Koy J, Krause M, Kupsch A, Lorenz D, Lorenzl S, Mehdorn HM, Moringlane JR, Oertel W, Pinsker MO, Reichmann H, Reuss A, Schneider GH, Schnitzler A, Steude U, Sturm V, Timmermann L, Tronnier V, Trottenberg T, Wojtecki L, Wolf E, Poewe W, Voges J; German Parkinson Study Group, Neurostimulation Section. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med. 2006 Aug 31;355(9):896-908. doi: 10.1056/NEJMoa060281. | |
| 22170276 |
| Label | URL |
|---|---|
| German Research Collaboration, funded by the German Ministery of Research | View source |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Cologne |
| 50931 |
| Germany |
| Neurologische Klinik der Universität, Moorenstr. 5 | Düsseldorf | 40225 | Germany |
| Neurologische Klinik der Universität, Neuenheimerfeld 400 | Heidelberg | 69120 | Germany |
| Department of Neurology, Schittenhelmstr. 10 | Kiel | 24105 | Germany |
| Neurologische Klinik der Universität | München | 81337 | Germany |
| Derived |
| Daniels C, Krack P, Volkmann J, Raethjen J, Pinsker MO, Kloss M, Tronnier V, Schnitzler A, Wojtecki L, Botzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G, Witt K. Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable? Mov Disord. 2011 Dec;26(14):2516-21. doi: 10.1002/mds.23907. Epub 2011 Aug 25. |
| 21733529 | Derived | Witt K, Daniels C, Krack P, Volkmann J, Pinsker MO, Kloss M, Tronnier V, Schnitzler A, Wojtecki L, Botzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G. Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease. J Neurol Sci. 2011 Nov 15;310(1-2):261-6. doi: 10.1016/j.jns.2011.06.028. Epub 2011 Jul 5. |
| 20589868 | Derived | Daniels C, Krack P, Volkmann J, Pinsker MO, Krause M, Tronnier V, Kloss M, Schnitzler A, Wojtecki L, Botzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G, Witt K. Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease. Mov Disord. 2010 Aug 15;25(11):1583-9. doi: 10.1002/mds.23078. |
| 18538636 | Derived | Witt K, Daniels C, Reiff J, Krack P, Volkmann J, Pinsker MO, Krause M, Tronnier V, Kloss M, Schnitzler A, Wojtecki L, Botzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G. Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study. Lancet Neurol. 2008 Jul;7(7):605-14. doi: 10.1016/S1474-4422(08)70114-5. Epub 2008 Jun 4. |
| Homepage Coordination Center for Clinical Studies to STN Study, Language: German | View source |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |