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To investigate the clinical efficacy of femtosecond laser-assisted autologous lamellar keratoplasty in treating corneal dermoids.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Limbal autograft | Experimental | Corneal dermoid tumor resection combined with femtosecond laser assisted limbal autograft |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Limbal autograft | Procedure | Simple dermoid excision will be performed, followed by closure of the bare sclera and cornea by sutured femtosecond laser-assisted limbal autograft. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Corneal Thickness | To measure corneal thickness using anterior segment optical coherence tomography. | 1 week, 1 month, 3 months, 6 months, 9 months, 12 months and 18 months postoperatively |
| Corneal Transparency | The transparency and appearance of the cornea will be observed using slit-lamp microscopy | Preoperatively, 1 week, 1 month, 3 months, 6 months, 9 months, 12 months and 18 months postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Best corrected visual acuity | To measure best corrected visual acuity using ETDRS chart or Teller Acuity Cards. | Preoperatively, 1 week, 1 month, 3 months, 6 months, 9 months, 12 months and 18 months postoperatively |
| Corneal power, astigmatism and aberration |
| Measure | Description | Time Frame |
|---|---|---|
| Restoration of corneal surface | Restoration of a completely epithelized, stable, and avascular corneal surface. | 1 week, 1 month, 3 months, 6 months, 9 months, 12 months and 18 months postoperatively |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yizhi Liu, M.D.Ph.D. | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Ting Huang, M.D.Ph.D. | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center, Sun Yat-sen Univerisity | Guangzhou | Guangdong | 510070 | China |
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| Femtosecond laser | Device | A commercial femtosecond laser to create a particular shaped graft for transplantation |
|
To measure the changes of corneal power, astigmatism and aberration using autorefractor keratometer and wavefront aberrometer respectively. |
| Preoperatively, 1 week, 1 month, 3 months, 6 months, 9 months, 12 months and 18 months postoperatively |
| Cosmetic improvement | A grading system from 0 to 4 with slit-lamp photographs will be used to determine cosmetic result of each graft. | Preoperatively, 1 week, 1 month, 3 months, 6 months, 9 months, 12 months and 18 months postoperatively |