Evaluation of Lipid Emulsion on GCX in Critically Ill Patients

Alterations of Glycocalyx in Critical Illness and During Major Surgery and Approaches for Glycocalyx Protection. Effect of Parenteral Nutrition and Plasma Lipidome on GCX

Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx.

The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled.

Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),

Inclusion Criteria:

• patients in ICU
• indication for lipid administration as a part of TPN

Exclusion Criteria:

• shock or clinical/laboratory signs of tissue hypoperfusion
• previous lipid infusions (within 3 months before entering study)
• hyperlipidaemia
• hyperglycaemia (over 10 mmol/l)
• current or previous (within 72 hours before entering the study) use of propofol
• pancreatitis
• severe liver failure
• current use of statins