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The aim of this study is to study the per and post-exertional variations of the pro and anti inflammatory markers during an ultra-endurance race in healthy volunteers.
Study per and post-exertional changes in proinflammatory biological (IL1, IL6, TNF alpha, HMG beta1 and CRP) and anti inflammatory parameters (IL4, IL10 and IL13, TGF beta, LPS, lipoproteins, lipids) during an ultra endurance race.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample | Biological | Study per and post-exertional changes in proinflammatory biological (IL1, IL6, TNF alpha, HMG beta1 and CRP) and anti inflammatory parameters (IL4, IL10 and IL13, TGF beta, LPS, lipoproteins, lipids) during an ultra endurance race. |
| Measure | Description | Time Frame |
|---|---|---|
| Per and post-exertional variations of IL1 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL1 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of IL6 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL6 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of TNF alpha during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of TNF alpha blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of HMG beta during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of HMG beta blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of CRP during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of CRP blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of IL4 during an ultra-endurance race in healthy volunteers. |
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Inclusion Criteria:
Exclusion Criteria:
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25 healthy adult volunteers amateurly participating in the "100 miles South of France 2017 race ©" recruited electronically using an announcement on the race website.
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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In this study, the investigators will measure variations of IL4 blood level |
| Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of IL10 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL10 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of IL13 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL13 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of lipids during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of lipids blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of LPS during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of LPS blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of lipoprotein during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of lipoprotein blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| Per and post-exertional variations of TGF beta during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of TGF beta blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |