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The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ritalin (methylphenidate) then placebo | Experimental |
| |
| placebo then Ritalin (methylphenidate) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ritalin (methylphenidate)10Mg Tablet | Drug | oral ingestion of 3 tablets in a single-dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| coefficient of sensitivity to reward | Parameter characterizing the influence of reward expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration |
| Measure | Description | Time Frame |
|---|---|---|
| coefficient of sensitivity to effort | Parameter characterizing the influence of effort expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre d'investigation clinique, Institut du Cerveau et de la Moelle | Paris | 75013 | France |
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| ID | Term |
|---|---|
| D053609 | Lethargy |
| D007175 | Impulsive Behavior |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D008774 | Methylphenidate |
| ID | Term |
|---|---|
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Placebo Oral Tablet | Drug | oral ingestion of 3 tablets in a single-dose |
|
| coefficient of sensitivity to punishment | Parameter characterizing the influence of punishment expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration |
| coefficient of sensitivity to delay | Parameter characterizing the influence of delay expectation onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |