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| Name | Class |
|---|---|
| INSERM UMR-S 1139 | UNKNOWN |
| URC-CIC Paris Descartes Necker Cochin | OTHER |
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The aim of the study is to setup a collection of maternal plasma and serum from patients with preeclampsia and normal pregnancy for in vitro validation of new therapeutics based on extra-corporal removal of sFlt-1
A collection of maternal plasma and serum from patients with preeclampsia (PE) and normal pregnancy (NP) :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| preeclampsia | pregnancy with preeclampsia |
| |
| control | pregnancy without preeclampsia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| A collection of maternal plasma and serum | Biological | A collection of maternal plasma and serum from patients with preeclampsia (PE) and normal pregnancy (NP) |
|
| Measure | Description | Time Frame |
|---|---|---|
| ratio sFlt-1/PlGF | measurement of of sFlT-1 and PlGF | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Kinetics of these ratios sFlt-1/PlGF during pregnancy | measurement of of sFlT-1 and PlGF at many times | until 5 month |
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Inclusion Criteria:
Exclusion Criteria:
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pregnancy with preeclampsia and without preeclampsia
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| Name | Affiliation | Role |
|---|---|---|
| Edouard Lecarpentier, MD, PhD | Centre Hospitalier intercommunal de Créteil | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Cochin | Paris | 75014 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 14602804 | Background | Tsatsaris V, Goffin F, Munaut C, Brichant JF, Pignon MR, Noel A, Schaaps JP, Cabrol D, Frankenne F, Foidart JM. Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences. J Clin Endocrinol Metab. 2003 Nov;88(11):5555-63. doi: 10.1210/jc.2003-030528. | |
| 26405111 |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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Blood
| Thadhani R, Hagmann H, Schaarschmidt W, Roth B, Cingoez T, Karumanchi SA, Wenger J, Lucchesi KJ, Tamez H, Lindner T, Fridman A, Thome U, Kribs A, Danner M, Hamacher S, Mallmann P, Stepan H, Benzing T. Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia. J Am Soc Nephrol. 2016 Mar;27(3):903-13. doi: 10.1681/ASN.2015020157. Epub 2015 Sep 24. |
| 14764923 | Background | Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004 Feb 12;350(7):672-83. doi: 10.1056/NEJMoa031884. Epub 2004 Feb 5. |
| 31079531 | Result | Trapiella-Alfonso L, Alexandre L, Fraichard C, Pons K, Dumas S, Huart L, Gaucher JF, Hebert-Schuster M, Guibourdenche J, Fournier T, Vidal M, Broutin I, Lecomte-Raclet L, Malaquin L, Descroix S, Tsatsaris V, Gagey-Eilstein N, Lecarpentier E. VEGF (Vascular Endothelial Growth Factor) Functionalized Magnetic Beads in a Microfluidic Device to Improve the Angiogenic Balance in Preeclampsia. Hypertension. 2019 Jul;74(1):145-153. doi: 10.1161/HYPERTENSIONAHA.118.12380. Epub 2019 May 13. |