The Impact of E-liquid Nicotine Content on Reinforcement in Current Smokers

The Impact of E-liquid Nicotine Content on Reinforcement in Current Smokers

Participants will complete a phone screen and then one laboratory session. After completing in-person screening assessments, eligible participants will complete additional questionnaires. Participants will then choose an e-liquid flavor to use for the rest of the session. Participants will then sample two e-liquids that vary in nicotine content from little or no nicotine to a moderate level of nicotine, and questionnaires evaluating the subjective effects of each one. Participants will then complete a preference assessment where they choose between the two e-liquids. Participants will be blind to the nicotine contents.

Inclusion Criteria:

• At least 18 years old
• Daily cigarette smoking
• Have tried vaping devices on a minimum of one lifetime occasion

Exclusion Criteria:

• Unwilling to use a vaping device during the session
• Break alcohol level > 0.01 (g/dL)
• Pregnant, trying to become pregnant, or breastfeeding
• Systolic BP greater than or equal to 160 mm/Hg or below 90 mm/Hg
• Diastolic BP greater than or equal to 100 mm/Hg or below 50 mm/Hg
• Heart rate greater than or equal to 105 bpm or lower than 45 bpm
• A current upper respiratory infection, recent cardiac event (in the last year), Buerger disease, irregular heartbeat or arrhythmia within the last year, previous allergic or adverse reaction to nicotine