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| Name | Class |
|---|---|
| Salk Institute for Biological Studies | OTHER |
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The investigators intend to measure the health impact of a dietary intervention known as time restricted feeding (TRF) on patients with metabolic syndrome (three or more of: increased waist circumference, abnormal cholesterol levels, elevated blood pressure, or elevated blood sugar). The investigators will enroll patients with metabolic syndrome who eat for ≥ 14 hours per day and will ask participants to reduce daily oral intake to 10 hours per day. The investigators will assess the impact of this dietary change using measures obtained before and after a 12 week intervention period, including body mass index, blood pressure, various lab parameters and blood sugar levels (assessed using a continuous glucose monitor). The investigators will assess for compliance with TRF using a Smart Phone application (myCircadianClock (mCC) app).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Time Restricted Feeding | Experimental | Patients will reduce daily oral intake to 10 hours per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Time Restricted Feeding | Behavioral | Participants will reduce the amount of time they eat to 10 hours per day and will log their dietary intake using a smartphone application. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean blood glucose | Measured using a continuous glucose monitoring (CGM) device | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin, triglycerides, hs-CRP levels | Measured by blood test | 12 weeks |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pam Taub, MD | UCSD | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCSD | La Jolla | California | 92037 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25470547 | Background | Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 2014 Dec 2;20(6):991-1005. doi: 10.1016/j.cmet.2014.11.001. | |
| 25766238 | Background | Gill S, Le HD, Melkani GC, Panda S. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science. 2015 Mar 13;347(6227):1265-9. doi: 10.1126/science.1256682. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 7, 2022 | |
| Reset | Jul 26, 2023 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 7, 2022 | Jul 26, 2023 |
| ID | Term |
|---|---|
| D015431 | Weight Loss |
| D024821 | Metabolic Syndrome |
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |