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This is a pilot randomized control trial randomizing patients presenting in opioid withdrawal to the emergency department to receive either one of clonidine (usual standard of care) or buprenorphine for their opioid withdrawal. Primary treatment outcome is attendance at a rapid access addiction medicine clinic within a few days of emergency room presentation. Secondary treatment outcome is treatment status with respect to opioid agonist treatment at one month post emergency room visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Buprenorphine | Experimental | Patient receives buprenorphine in the emergency room based on a clinical trial protocol as well as a take home prescription for buprenorphine |
|
| Clonidine | Active Comparator | Patient receives clonidine in the emergency room based on a clinical trial protocol and also receives a take home prescription for clonidine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Buprenorphine | Drug | The participant receives buprenorphine |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants attending the rapid access clinic | The number of participants who attend a rapid access clinic assessment after initial enrollment | 2-5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who are on opioid agonist treatment | The number of participants who are maintained on some form of opioid agonist treatment at the one-month mark | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anita Srivastava, MD | University of Toronto | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31088887 | Derived | Srivastava A, Kahan M, Njoroge I, Sommer LZ. Buprenorphine in the emergency department: Randomized clinical controlled trial of clonidine versus buprenorphine for the treatment of opioid withdrawal. Can Fam Physician. 2019 May;65(5):e214-e220. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 6, 2017 | |
| Reset | Nov 2, 2017 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 6, 2017 | Nov 2, 2017 |
| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D004630 | Emergencies |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D002047 | Buprenorphine |
| D003000 | Clonidine |
| ID | Term |
|---|---|
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
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| Clonidine |
| Drug |
The participant receives clonidine |
|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006572 |
| Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D048288 | Imidazolines |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |