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This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low remifentanil and high sevoflurane | Active Comparator | Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %. |
|
| High remifentanil and low sevoflurane | Experimental | Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endotracheal intubation using laryngoscope | Procedure | Endotracheal intubation was done using laryngoscope for general anesthesia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with sore throat | At 24 hr |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with sore throat | At 0, 2, 4 and 24 hr | |
| Number of participants with hoarseness | At 0, 2, 4 and 24 hr | |
| Number of participants with cough |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hyun-Chang Kim, MD. Ph. D. | Keimyung University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Keimyung University | Daegu | Non-US/Canada | 137-040 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30558006 | Derived | Park JH, Lee YC, Lee J, Kim H, Kim HC. The influence of high-dose intraoperative remifentanil on postoperative sore throat: a prospective randomized study: A CONSORT compliant article. Medicine (Baltimore). 2018 Dec;97(50):e13510. doi: 10.1097/MD.0000000000013510. |
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| High remifentanil | Drug | Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min. |
|
| Low remifentanil | Drug | Remifentanil was administered as 0.1 mcg/kg/min. |
|
| High sevoflurane | Drug | Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %. |
|
| Low sevoflurane | Drug | Sevoflurane was administered as 0.5 MAC. |
|
| At 0, 2, 4 and 24 hr |
| Number of participants with nausea | At 0, 2, 4 and 24 hr |
| Number of participants with vomiting | At 0, 2, 4 and 24 hr |
| Number of participants with additional pain medication | At 0, 2, 4 and 24 hr |
| Visual analogue scale of postoperative pain | At 0, 2, 4 and 24 hr |
| Number of participants with shivering | At 0, 2, 4 and 24 hr |
| Requirements of analgesics | At 0, 2, 4 and 24 hr |
| ID | Term |
|---|---|
| D010612 | Pharyngitis |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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