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The mechanisms of bariatric surgery-induced weight loss go beyond reductions in calorie intake and may involve several other pathways. Recently, brown adipose tissue (BAT) has been added as another potential player. Activation of BAT results in enhanced energy expenditure and promotes weight loss. Here, the investigators will study the effects of bariatric surgery on BAT function by PET/CT studies and molecular analyses of adipose biopsies. The investigators will explore different pathways that may affect BAT activation in this patient population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bariatric Surgery | Experimental | Patients will undergo either Omega Loop Gastric Bypass or Sleeve Gastrectomy. The decision which type of surgery will be performed, will by made by the surgeon and the patient based on clinical considerations and the patient's wishes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bariatric Surgery | Procedure | Patients will undergo bariatric surgery as routinely scheduled. The type of bariatric procedure will be suggested by the surgeon based on clinical considerations. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in BAT activity after bariatric surgery | The primary outcome of this study is to determine whether Omega Loop Gastric Bypass and Sleeve Gastrectomy result in increased BAT activity | 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| Bariatric surgery-induced changes in gut microbiota, bile acid composition and other circulating factors | Any pre-versus postsurgical changes of the gut microbiota or bile acid composition or other circulating factors will be evaluated. | 4 years |
| Association between changes in BAT activity, transcriptional BAT markers and alterations in the gut microbiota profile or bile acid composition |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Florian Kiefer, MD,PHD | Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42059078 | Derived | Kulterer OC, Herz CT, Pils D, Wollenweber T, Fritzer-Szekeres M, Kautzky-Willer A, Calabretta R, Hagn G, Hacker M, Gerner C, Haug AR, Kiefer FW. Active Brown Adipose Tissue Is Associated With Reduced Arterial Inflammation and Less Atherogenic Circulating Factors in Individuals With Obesity. Arterioscler Thromb Vasc Biol. 2026 Apr 30. doi: 10.1161/ATVBAHA.125.324200. Online ahead of print. | |
| 40366070 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| ID | Term |
|---|---|
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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Linear regression analyses will be performed to determine any association between BAT activity or molecular signature and changes in the gut microbiota or bile acids |
| 4 years |
| Derived |
| Herz CT, Kulterer OC, Prager M, Marculescu R, Prager G, Kautzky-Willer A, Hacker M, Trajanoski S, Kofeler HC, Galle B, Haug AR, Berry D, Kiefer FW. Bariatric surgery promotes recruitment of brown fat linked to alterations in the gut microbiota. Eur J Endocrinol. 2025 Apr 30;192(5):603-611. doi: 10.1093/ejendo/lvaf081. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |