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| Name | Class |
|---|---|
| National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | OTHER_GOV |
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The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participated in the study in 2012 to undergo follow-up examinations in 2017, in order to allow comparisons of current results with baseline data from 2012.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High altitude pulmonary hypertension | Highlanders with high altitude pulmonary hypertension living above 2500 m. | ||
| High altitude control | Healthy highlanders living above 2500 m. | ||
| Low altitude control | Healthy lowlanders living below 1000 m. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in pulmonary artery pressure | Difference in the change in mean pulmonary artery pressure (mPAP measured by echocardiography) 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in nocturnal arterial oxygen saturation | Difference in the change in the nocturnal arterial oxygen saturation 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| Survival |
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Inclusion Criteria:
Exclusion Criteria:
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Highlanders with high altitude pumonary hypertension living at an altitude of 2500-4000 m; healthy highlanders living at an altitude of 2500-4000 m; healthy lowlanders living at an altitude of <1000 m.
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| Name | Affiliation | Role |
|---|---|---|
| Talant M Sooronbaev, MD | NCCIM | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Center for Cardiology and Internal Medicine | Bishkek | 720040 | Kyrgyzstan |
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| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
| D012891 | Sleep Apnea Syndromes |
| D006976 | Hypertension, Pulmonary |
| D018450 | Disease Progression |
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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Cumulative incidence of death and relocation to lower altitudes between 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander |
| Year 2012 to 2017 |
| Progression of oxygen desaturation index | Difference in the change in the oxygen desaturation index 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| Progression of quality of life | Difference in the change in the mental and physical component score of the SF-36 questionnaire 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| Progression of cognitive performance | Difference in the change in the mean reaction time 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| Exercise performance | Difference in the change in 6 minute walk distance 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| Arterial blood gas analysis | Difference in the change in arterial blood gases 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander | Year 2012 to 2017 |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D008171 | Lung Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |