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This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ketamine | Active Comparator |
| |
| dexmedetomidine | Active Comparator |
| |
| bupivacaine | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketamine | Drug | patients receive local anesthetic wound infiltration with 1 mg /kg ketamine |
|
| Measure | Description | Time Frame |
|---|---|---|
| severity of pain at rest and on coughing | severity of pain at rest and on coughing will be assessed using a 10-cm Visual Analog Scale (0 = no pain and 10 = worst imaginable pain) | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| sedation | sedation by using sedation score | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| fatma el sherif, MD | South Egypt Cancer Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Egypt Cancer instIitute | Asyut | 171516 | Egypt |
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| ID | Term |
|---|---|
| D007649 | Ketamine |
| D020927 | Dexmedetomidine |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
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| dexmedetomidine | Drug | patients receive local anesthetic wound infiltration with 1µg/kg dexmedetomidine |
|
| bupivacaine | Drug | patients receive local anesthetic wound infiltration with bupivacaine 0.5 % diluted in 20 ml saline |
|
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000813 | Anilides |
| D000577 | Amides |
| D000814 | Aniline Compounds |
| D000588 | Amines |