Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.

Inclusion Criteria:

• ASA I-II patients
• age range (18-60) years,
• weight (50- 90) kg

Exclusion Criteria:

• allergy to study drugs
• significant cardiac disease
• respiratory disease
• renal disease
• hepatic disease