Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia

The Effect of Intravenous Combination Dexmedetomidine - Ketamine Versus Dexmedetomidine on Post-Operative Analgesia in Patients Undergoing Vaginal Hysterectomy Under Spinal Anesthesia

In this study the participants aim to Compare The Effect of Intravenous Combination Dexmedetomidine _ Ketamine versus Dexmedetomidine on Post-Operative Analgesia In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.

Inclusion Criteria:

• Patients who will accept written informed consent.
• Age: 21-65 years old.
• Sex: female.
• BMI: <35 kg/m2
• Physical status: American Society of Anesthesiology (ASA) of Grade I-II
• Type of operation: vaginal hysterectomy under spinal anesthesia.

Exclusion Criteria:

• Uncooperative patients
• Any contraindication for spinal anesthesia e.g. coagulopathy, infection at site of block, and hypersensitivity to any drug used in this study.
• Patients who are known to be drug dependent.