The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

The Effects of Dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Inclusion Criteria:

• Patients undergoing off - pump coronary artery bypass grafting
• ASA physical status III-IV
• Aged 40-70 years
• NYHA physical status II-III

Exclusion Criteria:

• Bradycardia
• Atrioventricular block
• Echocardiography suggested:LVEF <40%, LVED>65mm
• Allergic to the drugs