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| Name | Class |
|---|---|
| Norwegian School of Sport Sciences | OTHER |
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The HILT study is a prospective, single-blinded, randomized controlled trial comparing a high-intensity exercise training intervention with usual care among adult lung transplant recipients. Patients randomized to the training intervention arm will undergo individually tailored high-intensity exercise training (80-95% of maximum heart rate) three hours per week for 20 weeks. Training will be conducted at local fitness centers on a one-on-one basis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-Intensity Training | Experimental |
| |
| Usual Care | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-intensity training | Behavioral | The exercise program will include a cardiovascular warm-up, high intensity interval training and progressive resistance training (PRT). The intervention will focus on high-intensity training, mainly by uphill walking on a treadmill at 80-95 % of the maximal heart rate and PRT in three series at 6-12 RM by leg press, chest press, back extension, seat row, and front raises. During the first four weeks, the patients will be introduced to the program while focusing on safety, techniques and familiarization. The endurance intensity and strength load will then continuously increase based on the patients' improvement, tolerance of dyspnea, and feelings of well-being or fatigue on each exercise day. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in peak oxygen uptake | Measured by cardiopulmonary exercise test | 0-20 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in total body composition (fat, muscle and bone mass) | Measured by dual-energy x-ray absorptiometry (DEXA) | 0-20 weeks |
| Change in forced expiratory volume in one second (FEV1) | Measured by spirometry |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elisabeth Edvardsen, PhD | Oslo University Hospital, Norwegian School of Sport Sciences | Principal Investigator |
| Michael T Durheim, MD | Oslo University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital | Oslo | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34282853 | Derived | Gutierrez-Arias R, Martinez-Zapata MJ, Gaete-Mahn MC, Osorio D, Bustos L, Melo Tanner J, Hidalgo R, Seron P. Exercise training for adult lung transplant recipients. Cochrane Database Syst Rev. 2021 Jul 20;7(7):CD012307. doi: 10.1002/14651858.CD012307.pub2. |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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|
| 0-20 weeks |
| Change submaximal exercise capacity | Measured by 6-minute walk distance | 0-20 weeks |
| Change in leg strength | Measured by maximum leg press | 0-20 weeks |
| Change in upper body strength | Measured by maximum breast press | 0-20 weeks |
| Change in hand strength | Measured by grip strength dynamometer | 0-20 weeks |
| Change in health-related quality of life | Measured by Short Form 36 (SF-36) | 0-20 weeks |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |