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The aim of this study was to examine the effects of high intensity aerobic interval training (AIT) versus moderate continuous training (CON) in heart transplant recipients.
Clinically stable heart transplant recipients > 12 month or more after HTx, age > 18 years, willing and capable of giving written informed consent for study participation and anticipated to be able to participate in the study for 12 months were included from the Heart Centre, Rigshospitalet, Copenhagen University Hospital.
Patients were excluded due to unstable condition or postoperative complications, recent severe rejection episodes (>H1R < 3 month), physical disabilities which prevent participation and re-transplantation or multi-organtransplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high intense interval training | Other | Each AIT session consisted a 10 minute warm-up period followed by 16 minutes of interval training consisting of intervals of 4-3-2 and 1 minutes duration at 85-95% of their peak capacity separated by 2-4 min active rest. |
|
| continuous moderate training | Active Comparator | Continued exercise 45 min. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high intense interval training | Other | Each AIT session consisted a 10 minute warm-up period followed by 16 minutes of interval training consisting of intervals of 4-3-2 and 1 minutes duration at 85-95% of their peak capacity separated by 2-4 min active rest. |
| Measure | Description | Time Frame |
|---|---|---|
| VO2peak | baseline test before randomization
| baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month). |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial function (endoPAT) | After the release of the cuff the hyperemic response was recorded and the reactive hyperemia index (RHI) was calculated automatic independent of operator. (endoPAT) | baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month). |
| Quality of Life (QoL)SF-36 |
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Inclusion Criteria:
-stable Heart transplant recipients > 12 month or more after HTx, age > 18 years,< 80. willing and capable of giving written informed consent for study participation.
Exclusion Criteria:
unstable condition postoperative complications, recent severe rejection episodes (>H1R < 3 month), re-transplantation or multi-organtransplantation.
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| Name | Affiliation | Role |
|---|---|---|
| Christian H Dall, cand.scient | Bispebjerg Hospital, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiac Rehabilitation, Bispebjerg University Hospital | Copenhagen | 2400 | Denmark |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 13, 2024 | |
| Reset | Aug 15, 2024 | |
| Release | May 16, 2025 | |
| Reset | Jun 4, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 13, 2024 | Aug 15, 2024 | |||
| May 16, 2025 |
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| continuous moderate training | Other | Continued exercise 45 min. |
|
SF-36, information on Quality of Life |
| baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month). |
| HADS-a, HADS-d anxiety and depression | Symptoms of anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS). | baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month). |
| Bloodsamples/biomarkers. | Samples cooled on ice, centrifuged for 10 minutes and the plasma transferred to microtubes and stored at -80°C. Biomarkers analysed at department of biomedicine at University of Copenhagen. | baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month). |
| augmentation index (AI), endoPAT | Augmentation index (AI)derived from pulse wave analyses and is a measure of arterial stiffness, (EndoPAT). | baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month). |
| Jun 4, 2025 |