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The investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aEEG) on cardiac arrest patients receiving therapeutic hypothermia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Comatose cardiac arrest survivors |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amplitude integrated electroencephalography | Device | Frontal Amplitude-integrated Electroencephalogram in Early Prognostication After Cardiac Arrest |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2 | Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 uV. | at day 180 |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of time to normal trace to poor neurological outcome evaluated by CPC score 3 to 5 | Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 uV. |
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Inclusion Criteria:
Exclusion Criteria:
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Comatose cardiac arrest survivors treated with TH
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sang Hoon Oh, MD | Contact | 82-2-2258-1987 | ohmytweety@catholic.ac.kr |
| Name | Affiliation | Role |
|---|---|---|
| Kyu Nam Park, MD | Seoul St. Mary's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Changwon Hospital | Recruiting | Changwon | South Korea |
Web based Case Report Form
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D007035 | Hypothermia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
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| at day 180 |
| Comparison of unfavorable aEEG patterns to poor neurological outcome evaluated by CPC score 3 to 5 | Unfavorable aEEG patterns include flat trace (FT), burst-suppression (BS) and status epilepticus (SE). FT is defined as isoelectric activity. BS is defined as the virtual absence of activity (<2uV) between bursts of high voltage (>25 uV). SE was defined as repetitive epileptiform discharges with amplitudes >50 uV and a median frequency 1 Hz for >30 min. | at day 180 |
| Comparison of diffusion weighted image (DWI) to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 |
| Comparison of the levels of serum neuron specific enolase (NSE) to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 |
| Comparison of convulsive movement and electrical status epilepticus (SE) to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 |
| Chonnam National University | Recruiting | Gwangju | South Korea |
|
| Seoul St. Mary's hospital | Recruiting | Seoul | 06591 | South Korea |
|
| KEPCO Medical Center | Recruiting | Seoul | South Korea |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |