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This study aims to examine the prognostic value of 18 channel amplitude-integrated EEG (aEEG) in comatose cardiac arrest patients The study design is a prospective observational study. Cardiac arrest patients undergoing targeted temperature management (TTM) will participate in the study. Relation of aEEG in each channel with the neurologic outcome at 6 month after return of spontaneous circulation (ROSC) will be evaluated.
Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Good neurological outcome | CPC 1 and 2 at 6 month after ROSC |
| |
| Poor neurological outcome | CPC 3 to 5 at 6 month after ROSC |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multi-channel aEEG monitoring | Diagnostic Test | 18 channel aEEG monitoring in comatose TTM-treated patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to normal trace in each aEEG channel | Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels. | at day 180 |
| Measure | Description | Time Frame |
|---|---|---|
| TTNT threshold for neurologic prognostication in each aEEG channel | Using area under the curve (AUC) of each channel aEEG for neurological outcome, we will determine the best TTNT thresholds for good neurological outcome (CPC 1 to 2) in all aEEG channels. | at day 180 |
| Alpha delta ratio of each channel aEEG for good neurological outcome (CPC 1 to 2) |
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Inclusion Criteria:
Comatose cardiac arrest TTM treatment Multi channel aEEG monitoring
Exclusion Criteria:
Cerebral origin cardiac arrest Known epilepsy
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TTM treated cardiac arrest patients
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| Name | Affiliation | Role |
|---|---|---|
| Sang Hoon Oh | Seoul St. Mary's Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St. Mary's hospital | Seoul | 06591 | South Korea |
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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The percentage powers in the alpha, theta and delta bands and the ratio of the powers in different frequency bands (i.e., alpha/delta) will be calculated. Finally we will evaluate the prognostic values of these ratios of the different bands. |
| at day 180 |
| Comparison of prognostic value between aEEG and various predictors | We will compare the prognostic performances (i.e., sensitivity, specificity, AUC) for poor neurological outcome (CPC 3 to 5) between EEG and these predictors. | at day 180 |