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Sleep-disordered breathing (SDB) describes a group of disorders in which partial or complete cessation of breathing occurs many times throughout the night, resulting in daytime sleepiness or fatigue that interferes with a person's ability to function and reduces quality of life. Transplantation has become an important treatment modality for end-stage organ failure. Transplant recipients are now living longer and, hence, develop chronic adverse medical conditions. Furthermore, transplantation is associated with weight gain. Despite the high prevalence of poor sleep and cardiovascular conditions among transplant patients, SDB is not well studied in these patients.
The primary research objective is to evaluate the prevalence, incidence and type (central or obstructive) of SDB in patients after lung transplantation.
Secondary research objectives are the evaluation of correlations between severity of SDB and clinical findings (weight, medical therapy, heart function, lung function, renal function, graft failure, …). Furthermore, the investigators will evaluate the relationship between SDB and cardiovascular morbidity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SDB and lung transplantation | Polysomnography at 1 year after lung transplantation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention - Diagnostic polysomnography at 1 year after lung transplantation | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with SDB and type (central or obstructive) of SDB | Prevalence of different types of SDB after lung transplantation | 1 year after lung transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Echocardiography | Correlations between SDB and heart function | 1 year after lung transplantation |
| Lung function measurement | Correlations between SDB and lung function |
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Inclusion Criteria:
Exclusion Criteria:
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Patients 1 year after lung transplantation are systematically evaluated by polysomnography.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dries Testelmans, MD, PhD | Contact | 00 32 16 34 25 22 | dries.testelmans@uzleuven.be |
| Name | Affiliation | Role |
|---|---|---|
| Dries Testelmans, MD, PhD | UZ Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Leuven | Recruiting | Leuven | 3000 | Belgium |
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| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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| 1 year after lung transplantation |
| Blood analysis | Correlations between SDB and renal function | 1 year after lung transplantation |
| 24h blood pressure | Evaluation of relationship between hypertension and SDB | 1 year after lung transplantation |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |