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| Name | Class |
|---|---|
| The German Heart Foundation | OTHER |
| Deutsche Stiftung für Herzforschung | OTHER |
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Sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. This study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation.
Sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. This study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation, as this topic is hardly studied yet and previous reports suggest changes in the entity of sleep-disordered breathing through heart transplantation. The circumstances and the impact of sleep-disordered breathing or residuals in heart transplant patients is not well understood yet and will be subject of this study.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep-disordered breathing | Behavioral | Prevalence and dynamic of sleep-disordered breathing after heart transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Apnea Hypopnea Index | Change in Apnea Hypopnea Index (AHI /h) before and after heart transplantation | 30 days after heart transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Apnea Index | Change in Apnea Index (AI /h) before and after heart transplantation | 30 days after heart transplantation |
| Hypopnea Index | Change in Hypopnea Index (HI /h) before and after heart transplantation |
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Inclusion Criteria:
Exclusion Criteria:
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End-stage heart failure patients assigned and eligible for heart transplantation
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Herz- und Diabeteszentrum NRW | Bad Oeynhausen | North Rhine-Westphalia | 32545 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25242802 | Result | Fox H, Puehler T, Schulz U, Bitter T, Horstkotte D, Oldenburg O. Delayed recovery from Cheyne-Stokes respiration in heart failure after successful cardiac transplantation: a case report. Transplant Proc. 2014 Sep;46(7):2462-3. doi: 10.1016/j.transproceed.2014.06.063. | |
| 27938912 | Result | Basic K, Fox H, Spiesshofer J, Bitter T, Horstkotte D, Oldenburg O. Improvements of central respiratory events, Cheyne-Stokes respiration and oxygenation in patients hospitalized for acute decompensated heart failure. Sleep Med. 2016 Nov-Dec;27-28:15-19. doi: 10.1016/j.sleep.2016.10.006. Epub 2016 Oct 28. |
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| ID | Term |
|---|---|
| D020182 | Sleep Apnea, Central |
| D006333 | Heart Failure |
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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plasma, serum and urine samples
| 30 days after heart transplantation |
| Oxygen Desaturation Index | Change in Oxygen Desaturation (ODI /h) before and after heart transplantation | 30 days after heart transplantation |
| Time SaO2 < 90 (%) | Change in Time SaO2 < 90 (%) before and after heart transplantation | 30 days after heart transplantation |
| Respiration cycle length | Change in Respiration cycle lengths before and after heart transplantation | 30 days after heart transplantation |
| Health Questionnaires | Change in MLWH questionnaire, this questionnaires obtains patient's quality of life in a score (in points) | 30 days after heart transplantation |
| Health Questionnaires | ESS questionnaire, this questionnaires obtains patient's sleepiness in daily life in a score (in points) | 30 days after heart transplantation |
| Health Questionnaires | Short Form 12 Health Survey Questionnaire, this questionnaires obtains patient's health status in a score (in points) | 30 days after heart transplantation |
| Right heart catheter | Changes in right heart catheter before and after heart transplantation | 30 days after heart transplantation |
| Blood gas analysis | Changes in blood gas analyses before and after heart transplantation | 30 days after heart transplantation |
| 26612581 | Result | Oldenburg O, Wellmann B, Buchholz A, Bitter T, Fox H, Thiem U, Horstkotte D, Wegscheider K. Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients. Eur Heart J. 2016 Jun 1;37(21):1695-703. doi: 10.1093/eurheartj/ehv624. Epub 2015 Nov 26. |
| 41306066 | Derived | Potratz M, Manukyan T, Schramm R, Costard-Jackle A, Fuchs U, Morshuis M, Guenther SPW, Rojas SV, Rudolph V, Gummert JF, Fox H. Nocturnal Hypoxemic Burden Predicts Mortality in Patients Awaiting Heart Transplantation. J Sleep Res. 2026 Jun;35(3):e70256. doi: 10.1111/jsr.70256. Epub 2025 Nov 27. |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |