Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Inclusion Criteria:

• Major Patient (age ≥ 18 years)
• Community or associated peritonitis, operated and hospitalized in resuscitation
• Affiliation to a social security scheme

Exclusion Criteria:

• Allergy known to echinocandins
• Dying Patient
• Limitation of care
• Predictable duration of follow-up ≤ 10 days
• Transfusion within 3 months
• Patient minor, patient under guardianship or curatorship