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New rapid diagnostic strategies are warranted in intra-abdominal candidiasis (IAC). A previous retrospective study showed that one measure, the day of the surgery, of peritoneal 1.3-Beta-D-Glucan ≤ 310pg/ml could rule out an IAC. This strategy was independent of the patient underlying conditions and Candida risk factors. This study aimed to confirm these results with a multicenter prospective study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CASE (intra abdominal candidiasis) | Critically ill patients with a confirmed diagnosis of intra abdominal candidiasis (IAC) Definition of IAC : sterilely collected peritoneal fluid cultures that are positive for Candida spp. as determined by the signs and symptoms consistent with an active infection |
| |
| CONTROL (bacterial intra abdominal infection) | Critically ill patients with a non candida intra abdominal infection (bacterial peritonitis) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1.3 BETA D GLUCAN | Diagnostic Test | dosage of 1.3 BETA D GLUCAN in the peritoneal fluid obtained during surgery with the β-glucan test (Fujifilm Wako Chemicals, Osaka, Japan) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measure of 1.3 BDG in the peritoneal exudate of patient with intra-abdominal candidiasis | Value of 1.3 BDG in the peritoneal exudate in patient with intra-abdominal candidiasis in comparison with non intra-abdominal candidiasis | 1 DAY |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of 1.3 BDG in the serum of patient with intra-abdominal candidiasis | Coefficient of correlation between peritoneal and serum 1.3 BDG in patient with and without intra-abdominal candidiasis | DAY 1 and DAY 3 |
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Inclusion Criteria:
Exclusion Criteria:
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Inclusion of 200 patients. Among them, identification of : 50 Cases (confirmed intra abdominal candidiasis) and 50 controls (intra abdominal infection without candida).
If more than 50 cases, random selection. Identification of control by matching (with confounding factors of the 1.3 BDG test). If more than 50 controls after matching, random selection.
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| Name | Affiliation | Role |
|---|---|---|
| Emmanuel NOVY, MD | Central Hospital, Nancy, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHR Mercy | Metz | Lorraine | 57000 | France | ||
| PILI-FLOURY Sebastien |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Novy, E.; Laithier, F.-X.; Riviere, J.; Remen, T.; Losser, M.-R.; Guerci, P.; Machouart, M. Protocol for the pBDG2 Study: Prospective Evaluation of 1.3-β-D-Glucan in the Peritoneal Fluid for the Diagnosis of Intra-Abdominal Candidiasis in Critically Ill Patients. Microbiol. Res. 2021, 12, 196-203. https://doi.org/10.3390/microbiolres12010015 | ||
| 29991219 | Result | Novy E, Laithier FX, Machouart MC, Albuisson E, Guerci P, Losser MR. Determination of 1,3-beta-D-glucan in the peritoneal fluid for the diagnosis of intra-abdominal candidiasis in critically ill patients: a pilot study. Minerva Anestesiol. 2018 Dec;84(12):1369-1376. doi: 10.23736/S0375-9393.18.12619-8. Epub 2018 Jul 9. |
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all IPD that underlie results in a publication
Available from inclusion to end of participation of the included patient
Only access to IPD of patient of the own participating ICU Access by code
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| Besançon |
| 25030 |
| France |
| BOUHEMAD Belaid | Dijon | 21079 | France |
| POTTECHER Julien | Strasbourg | 67098 | France |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D058365 | Candidiasis, Invasive |
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D007239 | Infections |
| D002177 | Candidiasis |
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D000072742 | Invasive Fungal Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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