Human Metabolic Dynamics at Rest and During Aerobic Exercise Under Normobaric Normoxic and Moderate Hypoxic Conditions

MetaboDyn- Liquid-liquid Extraction of Single Drops of Whole Capillary Blood as a Reliable Method of Measuring Metabolic Effects of Exercise: A Pilot Study.

The aim is to define in detail metabolic pathways at rest and during aerobic exercise in normal and healthy men and women under normobaric normoxic and moderate hypoxic conditions, using metabolomics technologies based on minimally invasive sampling relying on gas chromatography and mass spectrometry.

Inclusion criteria:

• approval and written, informed consent
• healthy adults of varying fitness levels (age >18 years to 75 years)

Exclusion criteria:

• chronic illness requiring any medication
• pregnancy
• limitations regarding functioning in the hypoxic chamber
• inability to follow simple instructions
• relevant or severe abnormalities in medical history, physical examination, ECG routine laboratory parameters from blood and urine