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The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1. Participants without meditation experience | Other | Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. |
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| 2. Participant with a significant meditation experience | Other | Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. |
|
| 3. Participants without meditation experience | Other | Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). |
|
| 4. Participant with a significant meditation experience | Other |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magneto-encephalography (MEG) | Other | Magneto-encephalography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Anatomical MRI scan | Brain structure | Day 1 |
| Functional MRI scan | Brain activation: Haemodynamic response - BOLD signal. | Day1 |
| EEG | Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT^2/Hz | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral measure : Accuracy of the performed task actions | Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits | Day 1 |
| Psychophysics: Pain threshold |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sandrine SONIE, MD | Le Vinatier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Le Vinatier | Bron | 69500 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33790200 | Background | Zorn J, Abdoun O, Sonie S, Lutz A. Cognitive Defusion Is a Core Cognitive Mechanism for the Sensory-Affective Uncoupling of Pain During Mindfulness Meditation. Psychosom Med. 2021 Jul-Aug 01;83(6):566-578. doi: 10.1097/PSY.0000000000000938. | |
| 38091350 | Background | Poublan-Couzardot A, Lecaignard F, Fucci E, Davidson RJ, Mattout J, Lutz A, Abdoun O. Time-resolved dynamic computational modeling of human EEG recordings reveals gradients of generative mechanisms for the MMN response. PLoS Comput Biol. 2023 Dec 13;19(12):e1010557. doi: 10.1371/journal.pcbi.1010557. eCollection 2023 Dec. |
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| ID | Term |
|---|---|
| D019122 | Meditation |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026443 | Spiritual Therapies |
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Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
|
| Electro-encephalography (EEG) | Other | Electro-encephalography |
|
| Functional Magnetic Resonance Imaging (fMRI) | Other | Functional Magnetic Resonance Imaging |
|
| Anatomical Magnetic Resonance Imaging (aMRI) | Other | Anatomical Magnetic Resonance Imaging |
|
| Meditation | Other | Meditation |
|
Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient. |
| Day 1 |
| Psychophysiology : Respiration | Respiration rate: breaths/minute | Day 1 |
| Subjective experience of the participant | Day 1 |
| Studies biomarkers of inflammation | area of the inflamed site in mm^2, obtained by automatic image processing of a photography | Day 1 |
| Behavioral measure : Speed of the performed task actions | Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms. | Day 1 |
| Psychophysiology : Heart | Heart Rate: pulses/minute | Day 1 |
| Psychophysiology : Heart rate variability | Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms. | Day 1 |
| Psychophysiology : Muscles | Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV. | Day 1 |
| Psychophysiology : Eyes | Eye gaze position: relative to center of the screen, in imm | Day 1 |
| Psychophysiology : Pupillar response | Pupillar response: pupil diameter, in mm. | Day 1 |
| Electrogastrogram | Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute) | Day 1 |
| 33797842 | Background | Poletti S, Abdoun O, Zorn J, Lutz A. Pain regulation during mindfulness meditation: Phenomenological fingerprints in novices and experts practitioners. Eur J Pain. 2021 Aug;25(7):1583-1602. doi: 10.1002/ejp.1774. Epub 2021 Apr 22. |
| 38698150 | Background | Katyal S, Abdoun O, Mounier H, Lutz A. Reduced processing of afforded actions while observing mental content as ongoing mental phenomena. Sci Rep. 2024 May 2;14(1):10130. doi: 10.1038/s41598-024-60934-6. |
| 35358612 | Background | Fucci E, Poublan-Couzardot A, Abdoun O, Lutz A. No effect of focused attention and open monitoring meditation on EEG auditory mismatch negativity in expert and novice practitioners. Int J Psychophysiol. 2022 Jun;176:62-72. doi: 10.1016/j.ijpsycho.2022.03.010. Epub 2022 Mar 28. |
| 38386366 | Background | Fucci E, Abdoun O, Baquedano C, Lutz A. Ready to help, no matter what you did: Responsibility attribution does not influence compassion in expert Buddhist practitioners. J Exp Psychol Gen. 2024 Apr;153(4):1093-1111. doi: 10.1037/xge0001542. Epub 2024 Feb 22. |
| 39309211 | Background | Czajko S, Zorn J, Daumail L, Chetelat G, Margulies DS, Lutz A. Exploring the Embodied Mind: Functional Connectome Fingerprinting of Meditation Expertise. Biol Psychiatry Glob Open Sci. 2024 Aug 9;4(6):100372. doi: 10.1016/j.bpsgos.2024.100372. eCollection 2024 Nov. |
| 32311185 | Result | Zorn J, Abdoun O, Bouet R, Lutz A. Mindfulness meditation is related to sensory-affective uncoupling of pain in trained novice and expert practitioners. Eur J Pain. 2020 Aug;24(7):1301-1313. doi: 10.1002/ejp.1576. Epub 2020 May 7. |
| 31085447 | Result | Fucci E, Abdoun O, Lutz A. Auditory perceptual learning is not affected by anticipatory anxiety in the healthy population except for highly anxious individuals: EEG evidence. Clin Neurophysiol. 2019 Jul;130(7):1135-1143. doi: 10.1016/j.clinph.2019.04.010. Epub 2019 Apr 27. |
| 30658238 | Result | Abdoun O, Zorn J, Poletti S, Fucci E, Lutz A. Training novice practitioners to reliably report their meditation experience using shared phenomenological dimensions. Conscious Cogn. 2019 Feb;68:57-72. doi: 10.1016/j.concog.2019.01.004. Epub 2019 Jan 15. |
| D012064 |
| Relaxation Therapy |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |