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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A01442-49 | Other Identifier | ID-RCB |
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| Name | Class |
|---|---|
| Centre de recherche Cerveau et Cognition (CERCO) | UNKNOWN |
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Our main objective is to study how the extent of reorganization of the central auditory system is related to the binaural integration in cochlear implanted subjects with asymmetric hearing loss. Subjects with asymmetric hearing loss treated with a cochlear implant and a control group of normal hearing subjects will perform two tests for binaural integration (speech recognition in noise and spatial localization) and two tasks of non-linguistic sounds perception.
Cochlear implantation is the most efficient method to restore hearing in deaf patients. However, about 2/3 of patients have some residual hearing and these patients usually combine two types of auditory information (electrical and acoustical). It is important to know how the brain is processing during two distinct stimulations and how it is related to the auditory level of performance.
Patients and controls will undergo a positron emission tomography scan brain imaging session during a simplified voice/non-voice discrimination task. For each tasks and brain imaging sessions, patients will be stimulated either with the non-implanted ear (acoustical stimulation), the cochlear implant (electrical stimulation) and using both modalities in a binaural condition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asymmetric hearing loss | Other | Asymmetric hearing loss treated with a cochlear implant will undergo positron emission tomography scan. |
|
| Normal hearing subjects | Other | Normal hearing subjects will undergo positron emission tomography scan. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Positron emission tomography scan | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in auditory brain activation between cochlear implanted asymmetric hearing loss subjects and normal hearing subjects in the binaural condition. | Prior to the imaging session, patients performed two human voice interpretation tests. link between temporal activations and performances obtained in binaural integration tasks in the patient group. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| differences in auditory brain activation. | Auditory brain activation when the better ear is acoustically stimulated in asymmetric hearing loss subjects and when one ear is stimulated in normal hearing subjects. | Week 3 - Week 5 |
| Performance level and the pattern of brain activation. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mathieu Marx, Pr | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Toulouse - Hôpital Purpan | Toulouse | France | 31059 | France | ||
| CERCO |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35640270 | Result | Karoui C, Strelnikov K, Payoux P, Salabert AS, James CJ, Deguine O, Barone P, Marx M. Auditory cortical plasticity after cochlear implantation in asymmetric hearing loss is related to spatial hearing: a PET H215O study. Cereb Cortex. 2023 Feb 20;33(5):2229-2244. doi: 10.1093/cercor/bhac204. | |
| 31533581 | Result | Karoui C, James C, Barone P, Bakhos D, Marx M, Macherey O. Searching for the Sound of a Cochlear Implant: Evaluation of Different Vocoder Parameters by Cochlear Implant Users With Single-Sided Deafness. Trends Hear. 2019 Jan-Dec;23:2331216519866029. doi: 10.1177/2331216519866029. |
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Subjects with asymmetric hearing loss treated with a cochlear implant and a control group of normal hearing subjects
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|
Acoustical or electrical stimulation in asymmetric hearing loss cochlear implanted subjects. |
| Week 3 - Week 5 |
| the asymmetry in auditory brain activation for asymmetric hearing loss cochlear implanted subjects. | Electrical and acoustical stimulation will be used. | Week 3 - Week 5 |
| link between binaural hearing performances and auditory brain activation in the binaural condition. | For the group of cochlear implanted subjects with asymmetric hearing loss. | Week 3 - Week 5 |
| Toulouse |
| Midi-Pyrénées |
| 31052 |
| France |
| 30837546 | Result | Berland A, Collett E, Gaillard P, Guidetti M, Strelnikov K, Cochard N, Barone P, Deguine O. Categorization of everyday sounds by cochlear implanted children. Sci Rep. 2019 Mar 5;9(1):3532. doi: 10.1038/s41598-019-39991-9. |
| 29914727 | Result | Strelnikov K, Collett E, Gaillard P, Truy E, Deguine O, Marx M, Barone P. Categorisation of natural sounds at different stages of auditory recovery in cochlear implant adult deaf patients. Hear Res. 2018 Sep;367:182-194. doi: 10.1016/j.heares.2018.06.006. Epub 2018 Jun 12. |
| ID | Term |
|---|---|
| D003638 | Deafness |
| D014012 | Tinnitus |
| ID | Term |
|---|---|
| D034381 | Hearing Loss |
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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