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| Name | Class |
|---|---|
| BASF | INDUSTRY |
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To conduct a randomized, double-blind, controlled clinical trial to determine the independent and combined effects of dietary conjugated linoleic acid (CLA) and vitamin D supplementation on anabolic signaling, the expression of growth regulatory factors, and muscle protein turnover in older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conjugated linoleic acid (Tonalin) | Active Comparator | Conjugated linoleic acid (4000 mg Tonalin FFA 80 per day) |
|
| Vitamin D | Active Comparator | Vitamin D3 (2000 IU per day) |
|
| Conjugated linoleic acid and Vitamin D | Active Comparator | Conjugated linoleic acid (4000 mg Tonalin FFA 80) and Vitamin D (2000 IU) per day |
|
| Placebo | Placebo Comparator | Corn oil (4000 mg per day) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conjugated linoleic acid | Dietary Supplement | Intervention will last up to 8 weeks. Subjects will receive conjugated linoleic acid (4000 mg Tonalin FFA 80) daily. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in post-absorptive muscle protein synthesis | A stable isotope labelled amino acid infusion, in conjunction with blood and muscle tissue sampling and mathematical modelling analysis will be used to measure post-absorptive muscle protein synthesis. | Baseline and 8 weeks |
| Change in combined amino acid and insulin stimulated muscle protein synthesis | A stable isotope labelled amino acid infusion, in conjunction with insulin and mixed amino acid infusion, blood and muscle tissue sampling and mathematical modelling analysis will be used to measure muscle protein synthesis. | Baseline and 8 weeks |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bettina Mittendorfer, PhD | Washington University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Washington University | St Louis | Missouri | 63110 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32860399 | Derived | van Vliet S, Fappi A, Reeds DN, Mittendorfer B. No independent or combined effects of vitamin D and conjugated linoleic acids on muscle protein synthesis in older adults: a randomized, double-blind, placebo-controlled clinical trial. Am J Clin Nutr. 2020 Nov 11;112(5):1382-1389. doi: 10.1093/ajcn/nqaa240. |
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| ID | Term |
|---|---|
| D044243 | Linoleic Acids, Conjugated |
| D014807 | Vitamin D |
| D003314 | Corn Oil |
| ID | Term |
|---|---|
| D008041 | Linoleic Acids |
| D043371 | Fatty Acids, Omega-6 |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
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Randomized, double-blind, controlled clinical trial
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|
| Vitamin D | Dietary Supplement | Intervention will last up to 8 weeks. Subjects will receive vitamin D3 (2000 IU) daily. |
|
| Conjugated linoleic acid and Vitamin D | Dietary Supplement | Intervention will last up to 8 weeks. Subjects will receive conjugated linoleic acid (4000 mg Tonalin FFA 80) and vitamin D3 (2000 IU) daily. |
|
| Corn oil (placebo) | Other | Intervention will last up to 8 weeks. Subjects will receive corn oil (4000 mg) daily. |
|
| D008055 |
| Lipids |
| D012632 | Secosteroids |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D005224 | Fats, Unsaturated |
| D010938 | Plant Oils |
| D009821 | Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |