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| Name | Class |
|---|---|
| Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior. | OTHER_GOV |
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This study aim to evaluate the effects of 16 weeks of multicomponent training on postural control, cardiovascular and musculoskeletal systems in pre-frail elderly through nonlinear and linear measurements.
Frailty syndrome is described as a clinical state of vulnerability to stress resulting from the decline of resilience and physiological reserves associated with aging. It is also characterized by a reduction of the interaction between systems and that would be reflected by a loss of physiological complexity. Physical exercise, especially the multi-component, is pointed out as a key element in the intervention of frail elderly individuals. However, it is still unclear whether the improvement in functional capacity observed with this type of training would be related to changes in the physiological complexity of these elderly individuals. The aim of this study is to evaluate the effect of multi-component training on the dynamics of the cardiovascular, motor, neuromuscular and physical activity levels of pre-frail elderly. Thirty-six pre-frail elderly individuals will be divided into intervention (IG, n = 18) and control (CG, n = 18) groups at three different moments (pre-intervention, post-intervention, 16 weeks, and follow-up of detraining of 6 Weeks). The complexity will be evaluated by calculating the entropy of the biological signals: a) heart rate, blood pressure (in supine and orthostatic conditions), b) oscillations of the pressure center (in open, closed eyes, after standing in a chair And under dual-task cognitive condition), c) torque oscillations of the knee extensor muscle group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | The training group will perform a Physical Exercise as multicomponent training. |
|
| Control | No Intervention | The control group will only be evaluated, without any intervention. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical Exercise | Other | The intervention program will follow the recommendations of the American College of Sports Medicine (ACSM, 2009), including aerobic, muscle strength, flexibility and balance exercise. The duration of the intervention will be 16 weeks with sessions 60 min performed in three alternate days. |
| Measure | Description | Time Frame |
|---|---|---|
| Linear and nonlinear measurements of postural control | Sample Entropy; Approximate Entropy | Change from baseline sample entropy and approximate entropy at 16 weeks of multicomponent training and after 6 weeks of detraining |
| Linear and nonlinear measurements of cardiovascular system | Heart Rate Variability; Conditional Entropy | Change from baseline heart rate variability and conditional entropy at 16 weeks of multicomponent training and after 6 weeks of detraining |
| Linear and nonlinear measurements of musculoskeletal systems | Knee extensor torque complexity | Change from baseline knee extensor torque complexity at 16 weeks of multicomponent training and after 6 weeks of detraining |
| Cognition Measures | Addenbrooke's Cognitive Examination | Change from baseline addenbrooke's cognitive examination at 16 weeks of multicomponent training and after 6 weeks of detraining |
| Measure | Description | Time Frame |
|---|---|---|
| Functional Measures | Six-minute Walk Test | Change from baseline six-minute walk test at 16 weeks of multicomponent training and after 6 weeks of detraining |
| Functional Measures | Short Physical Performance Battery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anielle CM Takahashi, PhD | Universidade Federal de Sao Carlos | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal University of São Carlos | São Carlos | São Paulo | 13565-905 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39259383 | Derived | Carnavale BF, da Silva Santos VR, Farche ACS, Rossi PG, Fiogbe E, de Souza Buto MS, de Vassimon-Barroso V, de Medeiros Takahashi AC. Effects of a multicomponent training and detraining on frailty status, physical activity level, sedentary behavior patterns and physical performance of pre-frail older adults: a randomized controlled trial. Eur Geriatr Med. 2024 Dec;15(6):1701-1712. doi: 10.1007/s41999-024-01052-4. Epub 2024 Sep 11. |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Change from baseline short physical performance battery at 16 weeks of multicomponent training and after 6 weeks of detraining |