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L-carnitine and plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effect: a randomized clinical trial
the trial aims to compare L-carnitine and plus metformin in clomiphene-resistant obese PCOS women with placebo to state the reproductive and metabolic effects in form of pregnancy and insulin resistance parameters and lipid metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L-carnitine and Metformin | Experimental | L-carnitine and Metformin in Obese PCOS Women trying induction of ovulation with clomiphene citrate. |
|
| placebo | Active Comparator | placebo was given toObese PCOS Women trying induction of ovulation with clomiphene citrate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-carnitine and Metformin | Drug | L-carnitine plus Metformin was given Obese PCOS Women trying induction of ovulation with clomiphene citrate. |
|
| Measure | Description | Time Frame |
|---|---|---|
| pregnancy rate | number of women with clinical pregnancy | 3 momths |
| Measure | Description | Time Frame |
|---|---|---|
| ovulation rate | number of women with follicle >18mm. | 3 momths |
| abortion rate | number of women with abortions | 3 momths |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ibrahim A el sharkwy, MD | FACULTY OF MEDICINE ,ZAGAZIG UNIVERSITY | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zagazig University | Zagazig | Egypt |
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| ID | Term |
|---|---|
| D002331 | Carnitine |
| D008687 | Metformin |
| ID | Term |
|---|---|
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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|
| placebo | Drug | placebo was given Obese PCOS Women trying induction of ovulation with clomiphene citrate. |
|
| insulin resistance | fasting glucose and insulin | 3 momths |
| lipid metabolism | Triglyceride, cholesterol | 3 momths |
| D001645 |
| Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |