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Hepatitis B virus (HBV) infection remains one of the most serious health problems worldwide. Patients with chronic HBV infection are at an increased risk for developing hepatic cirrhosis, hepatocellular carcinoma and even death. Although some predictive factors of the outcome of chronic HBV infection were identified, more precisely determine the factors which are associated with the outcome in non-selected patients with chronic HBV infection are still needed. The investigators purpose is to constitute a observational cohort of non-selected Chinese patients to create a database of epidemiological, clinical, biological, virological, immunologic and therapeutic parameters, in order to determine factors associated with the outcome of chronic HBV infection.
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| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with antigen loss (HBeAg and HBsAg loss) | 20 years | |
| Cirrhosis | 20 years | |
| Hepatic decompensation | Development of hepatic decompensation will be defined by any of the following events: (1) Ascites or hepatic hydrothorax; (2)Variceal or portal hypertensive bleeding; (3)Hepatic encephalopathy | 20 years |
| Hepatocellular carcinoma (HCC) | The diagnosis of HCC will be made using the American Association for the Study of Liver Disease criteria. | 20 years |
| Death | Date and cause of death will be recorded. | 20 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients chronically infected with hepatitis B virus
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chao Wu, M.D., Ph.D | Contact | 86-25-83105890 | dr.wu@nju.edu.cn | |
| Rui Huang, M.D., Ph.D. | Contact | doctor_hr@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Third Hospital of Changzhou | Recruiting | Changzhou | Jiangsu | 213001 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38835029 | Derived | Wang J, Zhu L, Zhang Z, Zhang S, Pan Y, Li Y, Cao F, Jiang C, Fan T, Xiong Y, Liu J, Chen Y, Yin S, Tong X, Zhu C, Liu X, Li J, Wu C, Huang R. Lower HBV DNA level is associated with more severe liver fibrosis in HBeAg-positive chronic hepatitis B with normal alanine transaminase. Virol J. 2024 Jun 4;21(1):127. doi: 10.1186/s12985-024-02368-0. | |
| 37742745 |
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| ID | Term |
|---|---|
| D019694 | Hepatitis B, Chronic |
| ID | Term |
|---|---|
| D006509 | Hepatitis B |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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Liver biopsy tissue, blood (serum, plasma, and DNA)
| Huai'an No.4 People's Hospital | Recruiting | Huai'an | Jiangsu | 223300 | China |
|
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Recruiting | Nanjing | Jiangsu | 210008 | China |
|
| Nanjing Jiangbei People's Hospital | Recruiting | Nanjing | Jiangsu | 210048 | China |
|
| Suqian People's Hospital | Recruiting | Suqian | Jiangsu | 223800 | China |
|
| The Fifth People's Hospital of Suzhou | Recruiting | Suzhou | Jiangsu | 215007 | China |
|
| Yao R, Lu S, Xue R, Wang J, Qiu Y, Chen Y, Liu J, Zhu L, Zhan J, Jiang S, Yin S, Tong X, Ding W, Li J, Zhu C, Huang R, Wu C. NAFLD is associated with less severe liver fibrosis in chronic hepatitis B: A multi-center, retrospective study. Ann Hepatol. 2024 Jan-Feb;29(1):101155. doi: 10.1016/j.aohep.2023.101155. Epub 2023 Sep 24. |
| 36317959 | Derived | Wang J, Liu J, Liu Y, Xue R, Zhan J, Jiang S, Wang L, Yan X, Xiong Y, Xia J, Yin S, Tong X, Chen Y, Li J, Huang R, Wu C. Clinical features of chronic hepatitis B patients with lean nonalcoholic fatty liver disease. Hepatol Res. 2023 Mar;53(3):184-195. doi: 10.1111/hepr.13854. Epub 2022 Nov 21. |
| D018347 |
| Hepadnaviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D006525 | Hepatitis, Viral, Human |
| D006521 | Hepatitis, Chronic |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |