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| Name | Class |
|---|---|
| Sichuan Provincial People's Hospital | OTHER |
| The Fourth People's Hospital of Chengdu | OTHER |
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This study aims to 1) examine common and specific emotional and cognitive dysfunctions between Major Depression and generalized anxiety disorder; 2) Examine emotional and cognitive dysfunctions between the two disorders and healthy controls; 3) Examine the biomarkers predicting successful therapy or not.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Depression patients (MDD) | Patients with diagnosis of major depression according to DSM criteria |
| |
| Anxiety patients (GAD) | Patients with generalized anxiety disorder according to DSM criteria |
| |
| Healthy controls | Demographically matched healthy controls. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI | fMRI based indices during emotional face processing | 1 hour (assessed at study inclusion) |
| Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI | fMRI based indices during empathy processing | 1 hour (assessed at study inclusion) |
| Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI | fMRI based indices during working memory | 1 hour (assessed at study inclusion) |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral performance during the fMRI: face processing | Accuracy during face processing | 1 hour (assessed at study inclusion) |
| Behavioral performance during the fMRI: empathy reactivity | Empathy in response to empathy inducing pictures (rated on Likert scale) |
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Inclusion Criteria:
GAD:
MDD:
Exclusion Criteria:
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Patients from the hospitals and healthy controls from community
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Benjamin Becker, Dr. | Contact | ben_becker@gmx.de |
| Name | Affiliation | Role |
|---|---|---|
| Benjamin Becker, Dr. | School of Life Science and Technology, University of Electronic Science and Technology of China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Life Science and Technology, University of Electronic Science and Technology of China | Recruiting | Chengdu | Sichuan | 611731 | China |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| D000098647 | Generalized Anxiety Disorder |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
| D001008 | Anxiety Disorders |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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saliva
| 1 hour (assessed at study inclusion) |
| Behavioral performance during the fMRI: working memory | Working memory performance during fMRI | 1 hour (assessed at study inclusion) |
| Cognitive performance at study inclusion | Executive functions as assessed via computerized tests (CANTAB) | 1 hour (assessed at study inclusion) |
| Symptom improvement after 3 months: depression | Symptoms of depression will be assessed using validated clinical scales (e.g. BDI) | 3 months |
| Symptom improvement after 3 months: anxiety | Symptoms of generalized anxiety will be assessed using validated clinical scales (e.g. Penn State Worry Questionnaire) | 3 months |
| D003072 |
| Cognition Disorders |
| D019965 | Neurocognitive Disorders |